Immune Regulation of Pain: Friend and Foe

Overview

Journal Sci Transl Med

Specialties General Medicine
Science

Date 2021 Nov 10

PMID 34757809

Citations 24

Authors

Annemieke Kavelaars

Cobi J Heijnen

Affiliations

Soon will be listed here.

Abstract

The immune system and the peripheral sensory nervous system communicate through hardwired and humoral routes using shared mediators and receptors. On the basis of studies on pain sensitivity in rodents, the immune system can be viewed as both friend and foe. T cells and macrophages enhance pain via proinflammatory mediators and promote pain resolution via anti-inflammatory mediators and endogenous opioids.

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