Association of ACE I/D Gene Polymorphism and Related Risk Factors in Impaired Fasting Glucose and Type 2 Diabetes: a Study Among Two Tribal Populations of North-East India

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2021 Nov 10

PMID 34757597

Citations 1

Authors

Sunanda Rajkumari

Somorjit Singh Ningombam

Varhlun Chhungi

Masan Kambo Newmei

Naorem Kiranmala Devi

Prakash Ranjan Mondal

Kallur Nava Saraswathy

Affiliations

Soon will be listed here.

Abstract

Background: Type 2 diabetes is a serious public health concern in India, even the indigenous tribal populations are not left unaffected. The present study aims to understand the association of major risk factors i.e. obesity, hypertension, dyslipidemia, ACE I/D polymorphism with impaired fasting glucose (IFG) and type 2 diabetes (T2D) among two different Mendelian populations of North East India.

Methods: Demographic, somatometric, physiological variables along with fasting blood samples were collected from 609 individuals. The participants were screened for ACE I/D polymorphism.

Results: ACE I/D polymorphism was found to follow HWE among Liangmai tribe but not among Mizo tribe. Distribution of DD genotype/D allele was found to be significantly higher for T2D among Mizo tribe. Significant association were observed between DD genotype/D allele of ACE I/D polymorphism and TC as well as LDL with both IFG and T2D only in Mizo tribe.

Conclusions: The present study is an example of gene-environment interaction where DD genotype or D allele and dyslipidemia (high TC and high LDL) are posing risk for IFG and T2D both independently and in combination only among Mizo tribe with relatively less physical activity attributed to their residence in less hilly terrain however Liangmai tribe which resides in high hilly terrain shows no such association.

Citing Articles

Associations of ACE I/D and AGTR1 rs5182 polymorphisms with diabetes and their effects on lipids in an elderly Chinese population.

Liu J, Yi Y, Guo Q, Jia K, Li X, Cai J Lipids Health Dis. 2024; 23(1):231.

PMID: 39080710 PMC: 11290002. DOI: 10.1186/s12944-024-02222-w.

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