Polymorphism of ACE Gene As the Genetic Predisposition of Coronary Artery Disease in Eastern India

Overview

Journal Indian Heart J

Publisher Elsevier

Specialty Cardiology & Vascular Diseases

Date 2012 Dec 21

PMID 23253410

Citations 15

Authors

Soujatya Dhar

Saumitra Ray

Anjanlal Dutta

Bani Sengupta

Sila Chakrabarti

Affiliations

Soon will be listed here.

Abstract

Aim: A case control study was designed to assess whether the prevalence of ACE gene polymorphism has any role in the development of CAD.

Methods: The study included unrelated 217 cases with CAD and 255 healthy controls. PCR was done using primers followed by agarose gel electrophoresis for study of different ACE gene polymorphisms. Multiple logistic regression analysis was carried out to find association between studied genotypes and lifestyle as well as biochemical risk factors.

Results: Both DD [OR: 2.16; 95%CI: (60.60-67.40)] and ID [OR: 1.48; 95%CI: (93.28-97.72)] genotypes of the ACE gene showed significant associations in the development of CAD. Coexistence of diabetes and hypertension found to be risk modifier of the disease. Tobacco intake in various forms elevates the risk of the disease among the cases with risk genotypes.

Conclusion: ID and DD genotypes of ACE gene came out to be predisposing factors for the CAD cases in our study population.

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