Santin and Cirsimaritin from Betula Pubescens and Betula Pendula Buds Induce Apoptosis in Human Digestive System Cancer Cells

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2021 Nov 10

PMID 34755444

Citations 6

Authors

Lukasz Szoka

Jolanta Nazaruk

Marcin Stocki

Valery Isidorov

Affiliations

Soon will be listed here.

Abstract

Flavonoids are bioactive secondary metabolites of plants, which exert anti-cancer effects. However, metabolism in enterocytes and the liver can influence the biological activity of flavonoids contained in the diet. Therefore, results from in vitro studies on cancer cells from the digestive tract and liver may reflect the real effects in the human body. Previously, we have found that the extract from birch buds exerts antiproliferative activity in a panel of cancer cells. In the present study, the anti-cancer activity of ten flavonoids isolated from the buds of Betula pubescens and Betula pendula was characterized. Among them, santin and cirsimaritin significantly reduced viability, proliferation and clonogenicity of gastric (AGS), colon (DLD-1) and liver (HepG2) cancer cells. Both flavonoids induced apoptosis, accompanied by activation of caspase-3, caspase-7, caspase-8 and caspase-9. Moreover, upregulation of p53 was detected only in wild-type p53 harbouring cells. Together, our results suggest that santin and cirsimaritin exhibit promising anti-cancer activity in cultures of digestive system cancer cells.

Citing Articles

Dammarane-Type 3,4--Triterpenoid from Silver Birch ( Roth) Buds Induces Melanoma Cell Death by Promotion of Apoptosis and Autophagy.

Szoka L, Stocki M, Isidorov V Molecules. 2024; 29(17).

PMID: 39274939 PMC: 11397366. DOI: 10.3390/molecules29174091.

Prolidase-proline oxidase axis is engaged in apoptosis induction by birch buds flavonol santin in endometrial adenocarcinoma cell line.

Szoka L, Nazaruk J, Giegiel J, Isidorov V Front Mol Biosci. 2023; 10:1247536.

PMID: 37745688 PMC: 10512030. DOI: 10.3389/fmolb.2023.1247536.

Santin (5,7-Dihydroxy-3,6,4'-Trimetoxy-Flavone) Enhances TRAIL-Mediated Apoptosis in Colon Cancer Cells.

Klosek M, Jaworska D, Pietsz G, Szliszka E Life (Basel). 2023; 13(2).

PMID: 36836951 PMC: 9962120. DOI: 10.3390/life13020592.

The Current State of Knowledge in Biological Properties of Cirsimaritin.

Benali T, Jaouadi I, Ghchime R, El Omari N, Harboul K, Hammani K Antioxidants (Basel). 2022; 11(9).

PMID: 36139916 PMC: 9495358. DOI: 10.3390/antiox11091842.

New Polymethoxyflavones from Evoke DNA Biosynthesis-Inhibitory Activity in An Oral Squamous Carcinoma (SCC-25) Cell Line.

Strawa J, Jakimiuk K, Szoka L, Brzezinski K, Drozdzal P, Palka J Molecules. 2022; 27(14).

PMID: 35889288 PMC: 9325269. DOI: 10.3390/molecules27144415.

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