Laparoscopic Resection of Aortocaval Paraganglioma Diagnosed by Serial Increase in Urinary Metanephrines After Bilateral Adrenalectomy in a Patient with Multiple Endocrine Neoplasia Type 2A

Overview

Journal IJU Case Rep

Date 2021 Nov 10

PMID 34755052

Citations 1

Authors

Yushi Miyata

Koji Hatano

Yosuke Okuno

Takeshi Ujike

Shinichiro Fukuhara

Motohide Uemura

Hiroshi Kiuchi

Ryoichi Imamura

Michio Otsuki

Norio Nonomura

Affiliations

Soon will be listed here.

Abstract

Introduction: Although bilateral pheochromocytoma is prevalent in patients with multiple endocrine neoplasia type 2, extra-adrenal tumors rarely occur in the aortocaval area.

Case Presentation: A 35-year-old man with multiple endocrine neoplasia type 2A ( codon Cys634Arg mutation) underwent bilateral adrenalectomy for metachronous pheochromocytoma. After bilateral adrenalectomy, urinary metanephrines decreased below the measurement sensitivity. The levels of urinary metanephrines were serially elevating to a peak of 187 ng/mgCr during the 11-year follow-up period; however, urinary normetanephrine levels remained almost stable. I-metaiodobenzylguanidine single-photon emission computed tomography revealed abnormal accumulation with a mass of 25 × 18 mm in diameter in the aortocaval space cranially to the renal vessels. The extra-adrenal paraganglioma was successfully resected using transperitoneal laparoscopic surgery.

Conclusion: The serial increase in urinary metanephrine levels was useful for the detection of the recurrent tumor in a patient who had undergone bilateral adrenalectomy.

Citing Articles

Utility of Retroperitoneal Laparoscopic Surgery for Retroperitoneal Tumors.

Kira S, Sawada N, Mochizuki T, Ohtake Y, Shimura H, Suda R JSLS. 2025; 28(4.

PMID: 39803167 PMC: 11723572. DOI: 10.4293/JSLS.2024.00031.

Laparoscopic resection of aortocaval paraganglioma diagnosed by serial increase in urinary metanephrines after bilateral adrenalectomy in a patient with multiple endocrine neoplasia type 2A.

Miyata Y, Hatano K, Okuno Y, Ujike T, Fukuhara S, Uemura M IJU Case Rep. 2021; 4(6):347-350.

PMID: 34755052 PMC: 8560458. DOI: 10.1002/iju5.12345.

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