Interleukin-37 Gene Polymorphism and Susceptibility to Coronavirus Disease 19 Among Iraqi Patients

Overview

Journal Meta Gene

Publisher Elsevier

Specialty Genetics

Date 2021 Nov 3

PMID 34729360

Citations 8

Authors

Aeshah A Ahmed

Ali H Adhiah

Affiliations

Soon will be listed here.

Abstract

Coronavirus disease 19 (COVID-19) is a highly contagious respiratory viral infection. Dysregulated immune response is an important feature of disease, and cytokines are among the most important mediators of dysregulated immunity. Interleukin-37 (IL-37) is one such cytokine and studies have indicated its role in pathogenesis of COVID-19. However, gene polymorphisms have not been identified in patients with COVID-19. Therefore, this case-control study (100 patients and 100 controls) was performed to understand the role six single nucleotide polymorphisms of gene (SNPs: rs3811042, rs3811043, rs2466449, rs3811045, rs3811046 and rs3811047) in susceptibility to COVID-19 among cases with severe disease. These polymorphisms were identified by Sanger DNA sequencing. Results revealed that TG genotype of rs3811046 showed a significantly increased frequency in patients compared to controls (61.0 vs. 38.0%; odds ratio [OR] = 2.55; 95% confidence interval [CI] = 1.45-4.50; probability [] = 0.002; corrected [] = 0.01). GA genotype of rs3811047 also showed an increased frequency in patients but the -value was not significant (39.0 vs. 24.0%; OR = 2.02; 95% CI = 1.10-3.71; = 0.033; = 0.165). Haplotype analysis revealed a significantly increased frequency of the haplotype G-C-A-T-T-A (in the order: rs3811042, rs3811043, rs2466449, rs3811045, rs3811046 and rs3811047) in COVID-19 patients compared to controls (0.055 vs. 0.006; OR = 10.23; 95% CI = 1.53-68.14; = 0.003; = 0.03). In conclusion, the study indicated that two variants of gene (rs3811046 and rs3811047) may be associated with susceptibility to COVID-19 among Iraqi population.

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