Serum Interleukin-37 Level and Interleukin-37 Gene Polymorphism in Patients with Behçet Disease

Overview

Journal Clin Rheumatol

Publisher Springer

Specialty Rheumatology

Date 2018 Sep 19

PMID 30225559

Citations 7

Authors

Selcan Ozguclu

Turker Duman

Funda Seher Ozalp Ates

Orhan Kucuksahin

Sevgi Colak

Umit Olmez

Affiliations

Soon will be listed here.

Abstract

Behçet's disease (BD) is a chronic inflammatory disease. The etiopathogenesis of BD is not well understood and several cytokines and genetic factors have been investigated. Interleukin (IL)-37, which a member of IL-1 family is an anti-inflammatory cytokine. The aim of the study was to analyze serum IL-37 level and IL-37 gene polymorphisms to assess its possible role in BD. Two hundred twenty-three patients with BD and 80 healthy controls (HC) were enrolled. Serum IL-37 level was measured using an enzyme-linked immunosorbent assay (ELISA). Deoksiribo Nucleic acids (DNA) were extracted using a genomic DNA isolation kit. Single nucleotide polymorphism (SNP) of IL-37 gene (rs3811047) was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR/RFLP) methods. Serum IL-37 level was not significantly different in BD and HC (p > 0.05). Serum IL-37 level was not associated with the disease activity (p > 0.05). However, its level was higher in mucocutaneous involvement compared with systemic involvement (p = 0.002) and HC (p = 0.005). IL-37 gene polymorphisms were similar in BD and HC (p > 0.05). IL-37 may play a role in the etiopathogenesis of BD by contributing to manifestation with more moderate clinical symptoms.

Citing Articles

Genetics in Behcet's Disease: An Update Review.

Gao Y, Zhong Z, Yang P Front Ophthalmol (Lausanne). 2024; 2:916887.

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The intellectual base and research fronts of IL-37: A bibliometric review of the literature from WoSCC.

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Interleukin-37 gene polymorphism and susceptibility to coronavirus disease 19 among Iraqi patients.

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A single nucleotide polymorphism in the gene is associated with Behcet's disease in a Chinese Han population.

Liu X, Wu Z, Chen S, Zhao C, Gao F, Pei M Int J Ophthalmol. 2021; 14(9):1315-1320.

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