BPIFB1 Inhibits Vasculogenic Mimicry Via Downregulation of GLUT1-mediated H3K27 Acetylation in Nasopharyngeal Carcinoma

Overview

Journal Oncogene

Specialties Molecular Biology
Oncology

Date 2021 Nov 2

PMID 34725462

Citations 14

Authors

Xianjie Jiang

Xiangying Deng

Jie Wang

Yongzhen Mo

Lei Shi

Fang Wei

Shanshan Zhang

Zhaojian Gong

Yi He

Fang Xiong

Yumin Wang

Can Guo

Bo Xiang

Ming Zhou

Qianjin Liao

Xiaoling Li

Yong Li

Guiyuan Li

Wei Xiong

Zhaoyang Zeng

Affiliations

Soon will be listed here.

Abstract

Nasopharyngeal carcinoma (NPC) demonstrates significant regional differences and a high incidence in Southeast Asia and Southern China. Bactericidal/permeability-increasing-fold- containing family B member 1 (BPIFB1) is a relatively specific and highly expressed protein in the nasopharyngeal epithelium. BPIFB1 expression is substantially downregulated in NPC and is significantly associated with poor prognosis in patients with NPC. However, the specific molecular mechanism by which BPIFB1 regulates NPC is not well understood. In this study, we found that BPIFB1 inhibits vasculogenic mimicry by regulating the metabolic reprogramming of NPC. BPIFB1 decreases GLUT1 transcription by downregulating the JNK/AP1 signaling pathway. Altered glycolysis reduces the acetylation level of histone and decreases the expression of vasculogenic mimicry-related genes, VEGFA, VE-cadherin, and MMP2, ultimately leading to the inhibition of vasculogenic mimicry. To our knowledge, this is the first report on the role and specific mechanism of BPIFB1 as a tumor suppressor gene involved in regulating glycolysis and vasculogenic mimicry in NPC. Overall, these results provide a new therapeutic target for NPC diagnosis and treatment.

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