Metabolic Reprogramming and Epigenetic Modifications in Cancer: from the Impacts and Mechanisms to the Treatment Potential

Overview

Journal Exp Mol Med

Specialties Biochemistry
Molecular Biology

Date 2023 Jul 2

PMID 37394582

Authors

Xuemeng Xu

Qiu Peng

Xianjie Jiang

Shiming Tan

Yiqing Yang

Wenjuan Yang

Yaqian Han

Yuyu Chen

Linda Oyang

Jinguan Lin

Longzheng Xia

Mingjing Peng

Nayiyuan Wu

Yanyan Tang

JinYun Li

Qianjin Liao

Yujuan Zhou

Affiliations

Soon will be listed here.

Abstract

Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In cancer cells, metabolic pathway activity varies during tumorigenesis and cancer progression, indicating regulated metabolic plasticity. Metabolic changes are often closely related to epigenetic changes, such as alterations in the expression or activity of epigenetically modified enzymes, which may exert a direct or an indirect influence on cellular metabolism. Therefore, exploring the mechanisms underlying epigenetic modifications regulating the reprogramming of tumor cell metabolism is important for further understanding tumor pathogenesis. Here, we mainly focus on the latest studies on epigenetic modifications related to cancer cell metabolism regulations, including changes in glucose, lipid and amino acid metabolism in the cancer context, and then emphasize the mechanisms related to tumor cell epigenetic modifications. Specifically, we discuss the role played by DNA methylation, chromatin remodeling, noncoding RNAs and histone lactylation in tumor growth and progression. Finally, we summarize the prospects of potential cancer therapeutic strategies based on metabolic reprogramming and epigenetic changes in tumor cells.

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