Safety of Intravenous Arginine Therapy in Children with Sickle Cell Disease Hospitalized for Vaso-occlusive Pain: A Randomized Placebo-controlled Trial in Progress

Overview

Journal Am J Hematol

Specialty Hematology

Date 2021 Nov 1

PMID 34724240

Citations 7

Authors

Loretta Z Reyes

Janet Figueroa

Deborah Leake

Kirshma Khemani

Polly Kumari

Nitya Bakshi

Peter A Lane

Carlton Dampier

Claudia R Morris

Affiliations

Soon will be listed here.

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Impact of arginine therapy on kyotorphin in children with sickle cell disease and vaso-occlusive pain.

Korman R, Hatabah D, Brown L, Harris F, Wilkinson H, Rees C Blood Adv. 2024; 8(12):3267-3271.

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Sickle Cell Disease Treatment with Arginine Therapy (STArT): study protocol for a phase 3 randomized controlled trial.

Rees C, Brousseau D, Cohen D, Villella A, Dampier C, Brown K Trials. 2023; 24(1):538.

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Arginine Dysregulation and Myocardial Dysfunction in a Mouse Model and Children with Chronic Kidney Disease.

Reyes L, Winterberg P, George R, Kelleman M, Harris F, Jo H Nutrients. 2023; 15(9.

PMID: 37432321 PMC: 10181438. DOI: 10.3390/nu15092162.

Mitochondria: Emerging Consequential in Sickle Cell Disease.

Akhter M, Hamali H, Rashid H, Dobie G, Madkhali A, Mobarki A J Clin Med. 2023; 12(3).

PMID: 36769414 PMC: 9917941. DOI: 10.3390/jcm12030765.

References

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Morris C, Kuypers F, Lavrisha L, Ansari M, Sweeters N, Stewart M . A randomized, placebo-controlled trial of arginine therapy for the treatment of children with sickle cell disease hospitalized with vaso-occlusive pain episodes. Haematologica. 2013; 98(9):1375-82. PMC: 3762093. DOI: 10.3324/haematol.2013.086637. View

Lanzkron S, Carroll C, Haywood Jr C . The burden of emergency department use for sickle-cell disease: an analysis of the national emergency department sample database. Am J Hematol. 2010; 85(10):797-9. PMC: 3431910. DOI: 10.1002/ajh.21807. View

Morris C, Kato G, Poljakovic M, Wang X, Blackwelder W, Sachdev V . Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease. JAMA. 2005; 294(1):81-90. PMC: 2065861. DOI: 10.1001/jama.294.1.81. View

Morris C, Brown L, Reynolds M, Dampier C, Lane P, Watt A . Impact of arginine therapy on mitochondrial function in children with sickle cell disease during vaso-occlusive pain. Blood. 2020; 136(12):1402-1406. PMC: 7498366. DOI: 10.1182/blood.2019003672. View