Alpha 2.0
Login Register
» Articles » PMID: 34722015

Acute Endothelial Graft Rejection Following COVID-19 Infection

Overview
Journal Cureus
Specialty Biomedical Engineering
Date 2021 Nov 1
PMID 34722015
Citations 4
Authors
Geeta Behera
Tanmay Gokhale
Krishna R Babu
Affiliations
Soon will be listed here.
Abstract

Here, we report a case of acute endothelial graft rejection following coronavirus disease 2019 (COVID-19). A 57-year-old woman who underwent therapeutic penetrating keratoplasty for a perforated infectious corneal ulcer in her right eye developed severe acute respiratory syndrome coronavirus 2 infection, which required intensive care and treatment with steroids. Acute endothelial graft rejection was seen at three weeks postoperatively and managed with high-dose corticosteroids. Despite standard therapy, secondary graft failure was observed. Immune dysregulation associated with COVID-19 may be a significant cause of acute endothelial graft rejection among keratoplasty patients with COVID-19.

Citing Articles

Effect of the COVID-19 pandemic on Vogt-Koyanagi-Harada disease.

Muto T, Sakamoto M, Kusuda S, Haruyama Y, Machida S, Imaizumi S Sci Rep. 2024; 14(1):13211.

PMID: 38851824 PMC: 11162482. DOI: 10.1038/s41598-024-63957-1.

COVID and COVID vaccine-related corneal morbidity: A review.

Sidhu N, Vanathi M, Gupta N, Tandon R Indian J Ophthalmol. 2023; 71(12):3595-3599.

PMID: 37991289 PMC: 10788745. DOI: 10.4103/IJO.IJO_765_23.

Solid Organ Rejection following SARS-CoV-2 Vaccination or COVID-19 Infection: A Systematic Review and Meta-Analysis.

Alhumaid S, Rabaan A, Dhama K, Yong S, Nainu F, Hajissa K Vaccines (Basel). 2022; 10(8).

PMID: 36016180 PMC: 9412452. DOI: 10.3390/vaccines10081289.

Characteristics and Clinical Ocular Manifestations in Patients with Acute Corneal Graft Rejection after Receiving the COVID-19 Vaccine: A Systematic Review.

Fujio K, Sung J, Nakatani S, Yamamoto K, Iwagami M, Fujimoto K J Clin Med. 2022; 11(15).

PMID: 35956115 PMC: 9369681. DOI: 10.3390/jcm11154500.

References
1.
Singh G, Mathur U . Acute graft rejection in a COVID-19 patient: Co-incidence or causal association?. Indian J Ophthalmol. 2021; 69(4):985-986. PMC: 8012967. DOI: 10.4103/ijo.IJO_3701_20. View
2.
Wasser L, Roditi E, Zadok D, Berkowitz L, Weill Y . Keratoplasty Rejection After the BNT162b2 messenger RNA Vaccine. Cornea. 2021; 40(8):1070-1072. PMC: 8244807. DOI: 10.1097/ICO.0000000000002761. View
3.
Jin S, Juthani V . Acute Corneal Endothelial Graft Rejection With Coinciding COVID-19 Infection. Cornea. 2020; 40(1):123-124. PMC: 7513958. DOI: 10.1097/ICO.0000000000002556. View
4.
Ravichandran S, Natarajan R . Corneal graft rejection after COVID-19 vaccination. Indian J Ophthalmol. 2021; 69(7):1953-1954. PMC: 8374823. DOI: 10.4103/ijo.IJO_1028_21. View
5.
Phylactou M, Li J, Larkin D . Characteristics of endothelial corneal transplant rejection following immunisation with SARS-CoV-2 messenger RNA vaccine. Br J Ophthalmol. 2021; 105(7):893-896. DOI: 10.1136/bjophthalmol-2021-319338. View