Associations of Plasma 8-iso-prostaglandin Flevels with Fasting Blood Glucose (FBG) and Intra-abdominal Fat (IAF) Area in Various Glycometabolism Populations

Overview

Journal BMC Endocr Disord

Publisher Biomed Central

Specialty Endocrinology

Date 2021 Oct 29

PMID 34711211

Authors

Ning Ma

Yujian Zhang

Binbin Liu

Xiaojiao Jia

Rui Wang

Qiang Lu

Affiliations

Soon will be listed here.

Abstract

Background: This study aimed to investigate the differences in oxidative stress (OS) levels represented by 8-iso-prostaglandin F (8-iso-PGF) and analyze its correlation with the intra-abdominal fat (IAF) area and the glycolipid index.

Methods: We recruited a total of 160 eligible subjects. According to the blood glucose levels and the T2DM duration, subjects were divided into three groups: Type 2 Diabetes (T2DM) group, Prediabetic group, and Normal glucose-tolerance (NC) group, containing 66, 41, 53 patients, respectively. T2DM groups were additionally divided into a new-onset T2DM group including 29 patients and a non-new-onset T2DM group including 37 patients. General clinical data and biochemical indicators were collected. Intra-abdominal fat (IAF) was measured by MRI. 8-iso-PGF was measured by ELISA.

Results: Compared with the NC group, levels of systolic blood pressure (SBP), waist-to-hip ratio (WHR), FBG, 2 h postprandial glycemia(2hPG), 2 h insulin (2 h INS), IAF area, HOMA-IR, and 8-iso-PGF increased, and high-density lipoprotein cholesterol (HDL-C) decreased in T2DM groups and Prediabetic group (P < 0.05). The 2 h INS level was the highest in the Prediabetic group; 2hPG, and IAF area were the highest in the new-onset T2DM group; WHR, FBG, HOMA-IR and 8-iso-PGF were the highest in the non-new-onset T2DM group. Multiple stepwise regression analysis identified IAF area and FBG as the strongest and independent determinant of 8-iso-PGF (P < 0.01).

Conclusions: In various glycometabolism populations, 8-iso-PGF2α is significantly correlated with FBG and IAF, this suggests that high blood glucose and abdominal obesity can increase the damage related to the OS in vivo.

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