The Cohesin Complex and Its Interplay with Non-Coding RNAs

Overview

Journal Noncoding RNA

Date 2021 Oct 28

PMID 34707078

Citations 2

Authors

Merve Kuru-Schors

Monika Haemmerle

Tony Gutschner

Affiliations

Soon will be listed here.

Abstract

The cohesin complex is a multi-subunit protein complex initially discovered for its role in sister chromatid cohesion. However, cohesin also has several other functions and plays important roles in transcriptional regulation, DNA double strand break repair, and chromosome architecture thereby influencing gene expression and development in organisms from yeast to man. While most of these functions rely on protein-protein interactions, post-translational protein, as well as DNA modifications, non-coding RNAs are emerging as additional players that facilitate and modulate the function or expression of cohesin and its individual components. This review provides a condensed overview about the architecture as well as the function of the cohesin complex and highlights its multifaceted interplay with both short and long non-coding RNAs.

Citing Articles

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Current Status of Epitranscriptomic Marks Affecting lncRNA Structures and Functions.

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