Diagnostic Utility of Transbronchial Biopsy for Hodgkin's Lymphoma: A Case Study

Overview

Journal Thorac Cancer

Specialties Oncology
Pulmonary Medicine

Date 2021 Oct 26

PMID 34698453

Citations 1

Authors

Miki Hoshi

Nobuaki Kobayashi

Katsushi Tanaka

Kohei Somekawa

Ayami Kaneko

Ami Izawa

Kenichi Seki

Yoichi Tagami

Ayako Aoki

Hiroaki Fujii

Keisuke Watanabe

Nobuyuki Horita

Yu Hara

Mai Matsumura

Makiko Enaka

Maki Hagihara

Takeshi Kaneko

Affiliations

Soon will be listed here.

Abstract

Lung lesions of Hodgkin's lymphoma (HL) are rare and difficult to diagnose by nonsurgical biopsy. We herein present the case of a 72-year-old Japanese male who presented with accumulation of lung infiltrates and masses bilaterally on the lungs for 3 years. Although transbronchial lung biopsy (TBB) and computed tomography-guided biopsy were conducted several times, his diagnosis remained inconclusive. On further deterioration of lung lesions, the patient was transferred to our hospital. Positron emission tomography revealed increased accumulation in the bilateral lungs and right supraclavicular lymph nodes. Surgical biopsy of the lymph node was performed. He was finally diagnosed with HL and underwent chemotherapy with doxorubicin, vinblastine, dacarbazine, and brentuximab vedotin. After chemotherapy, the lung lesion showed significant regression. A literature review indicated that the diagnostic success rate of TBB was low (18.5%) in cases of lung lesions in HL.

Citing Articles

Diagnostic utility of transbronchial biopsy for Hodgkin's lymphoma: A case study.

Hoshi M, Kobayashi N, Tanaka K, Somekawa K, Kaneko A, Izawa A Thorac Cancer. 2021; 12(23):3281-3285.

PMID: 34698453 PMC: 8636206. DOI: 10.1111/1759-7714.14190.

References

Sinha A, Patti R, Singh P, Solomon W, Kupfer Y . A Diagnostic Surprise: Primary Hodgkin's Lymphoma of the Lung. J Investig Med High Impact Case Rep. 2017; 5(4):2324709617734247. PMC: 5637979. DOI: 10.1177/2324709617734247. View

Tahara M, Maekura T, Kasai T, Akira M . Primary Pulmonary MALT Lymphoma with Ground-glass Nodule. Intern Med. 2017; 56(22):3119-3120. PMC: 5725874. DOI: 10.2169/internalmedicine.9000-17. View

Conti L, Pisani D, Gatt A, Montefort S . Unusual case of primary pulmonary Hodgkin's lymphoma presenting with a continuous murmur. BMJ Case Rep. 2018; 2018. PMC: 6169648. DOI: 10.1136/bcr-2018-225674. View

van der Schee A, Dinkla B, van Knapen A . Primary pulmonary manifestation of Hodgkin's disease. Respiration. 1990; 57(2):127-8. DOI: 10.1159/000195833. View

Bianchi R, Dubini A, Asioli S, Ravaglia C, Tomassetti S, Puglisi S . Transbronchial cryobiopsy: an effective tool in the diagnosis of lymphoproliferative disorders of the lung. ERJ Open Res. 2020; 6(3). PMC: 7383053. DOI: 10.1183/23120541.00260-2019. View

Cartier Y, Johkoh T, Honda O, Muller N . Primary pulmonary Hodgkin's disease: CT findings in three patients. Clin Radiol. 1999; 54(3):182-4. DOI: 10.1016/s0009-9260(99)91012-7. View

Schild M, Wong W, Valdez R, Leis J . Primary pulmonary classical Hodgkin lymphoma: a case report. J Surg Oncol. 2014; 110(3):341-4. DOI: 10.1002/jso.23624. View

Honda A, Nakamura F, Nannya Y, Shintani Y, Fukayama M, Ichikawa M . Pulmonary lymphocyte-rich classical Hodgkin lymphoma with early response to ABVD therapy. Ann Hematol. 2013; 93(6):1073-4. DOI: 10.1007/s00277-013-1935-6. View

Yao D, Zhang L, Wu P, Gu X, Chen Y, Wang L . Clinical and misdiagnosed analysis of primary pulmonary lymphoma: a retrospective study. BMC Cancer. 2018; 18(1):281. PMC: 5848441. DOI: 10.1186/s12885-018-4184-1. View

10.

Urasinski T, Kamienska E, Gawlikowska-Sroka A, Ociepa T, Maloney E, Chosia K . Pediatric pulmonary Hodgkin lymphoma: analysis of 10 years data from a single center. Eur J Med Res. 2010; 15 Suppl 2:206-10. PMC: 4360309. DOI: 10.1186/2047-783x-15-s2-206. View

11.

Hoshi M, Kobayashi N, Tanaka K, Somekawa K, Kaneko A, Izawa A . Diagnostic utility of transbronchial biopsy for Hodgkin's lymphoma: A case study. Thorac Cancer. 2021; 12(23):3281-3285. PMC: 8636206. DOI: 10.1111/1759-7714.14190. View

12.

Guermazi A, Brice P, de Kerviler E E, Ferme C, Hennequin C, Meignin V . Extranodal Hodgkin disease: spectrum of disease. Radiographics. 2001; 21(1):161-79. DOI: 10.1148/radiographics.21.1.g01ja02161. View

13.

Yap E, Low I . Bronchoscopic Transbronchial Cryobiopsy Diagnosis of Recurrent Diffuse Large B-Cell Lymphoma in the Lung: A Promising New Tool?. J Bronchology Interv Pulmonol. 2017; 24(2):e22-e23. PMC: 5367508. DOI: 10.1097/LBR.0000000000000354. View

14.

Hosoi K, Chikuie N, Min K, Satoh T, Tokumine Y, Ishikawa K . [Primary pulmonary Hodgkin's disease]. Nihon Naika Gakkai Zasshi. 2005; 94(7):1399-401. DOI: 10.2169/naika.94.1399. View

15.

Parente P, Zanelli M, Zizzo M, Carosi I, Di Candia L, Sperandeo M . Primary pulmonary Hodgkin lymphoma presenting as multiple cystic lung lesions: diagnostic usefulness of cell block. Cytopathology. 2020; 31(3):236-239. DOI: 10.1111/cyt.12814. View

16.

Aljehani Y, Al-Saif H, Al-Osail A, Al-Osail E . Multiloculated Cavitary Primary Pulmonary Hodgkin Lymphoma: Case Series. Case Rep Oncol. 2018; 11(1):90-97. PMC: 5869374. DOI: 10.1159/000486824. View

17.

Stachura T, Malinowski E . Primary pulmonary Hodgkin's lymphoma with Epstein-Barr and cytomegaly virus infections. A case report and differential diagnosis. Pol J Pathol. 2003; 54(1):79-83. View

18.

Rodriguez J, Tirabosco R, Pizzolitto S, Rocco M, Falconieri G . Hodgkin lymphoma presenting with exclusive or preponderant pulmonary involvement: a clinicopathologic study of 5 new cases. Ann Diagn Pathol. 2006; 10(2):83-8. DOI: 10.1016/j.anndiagpath.2005.07.014. View

19.

Lowenthal B, Xu X, Subash M, Jih L . Hodgkin's lymphoma with unusual pulmonary presentations: Reporting two cases. Indian J Pathol Microbiol. 2017; 60(2):272-274. DOI: 10.4103/IJPM.IJPM_687_16. View

20.

Tanveer S, El Damati A, Baz A, Alsayyah A, Elsharkawy T, Regal M . Primary Pulmonary Hodgkin Lymphoma. Rare Tumors. 2016; 7(4):5968. PMC: 4703917. DOI: 10.4081/rt.2015.5968. View