An Exploratory Study of White Blood Cell Proportions Across Preeclamptic and Normotensive Pregnancy by Self-identified Race in Individuals with Overweight or Obesity

Overview

Journal Hypertens Pregnancy

Publisher Informa Healthcare

Date 2021 Oct 26

PMID 34697971

Citations 1

Authors

Mitali Ray

Lacey W Heinsberg

Yvette P Conley

James M Roberts

Arun Jeyabalan

Carl A Hubel

Daniel E Weeks

Mandy J Schmella

Affiliations

Soon will be listed here.

Abstract

Examine white blood cell (WBC) proportions across preeclamptic (n = 28 cases) and normotensive (n = 28 controls) pregnancy in individuals with overweight/obesity. WBC proportions were inferred from genome-wide DNA methylation data and compared by case/control status and self-identified race. In Trimester 1, ean B cell proportions were suggestively lower in cases in the overall sample and significantly lower in White participants but not in Black participants. More significant WBC proportion changes were observed across normotensive than preeclamptic pregnancy. These findings in a small sample demonstrate need for additional studies investigating the relationship between self-identified race and WBCs in pregnancy.

Citing Articles

A longitudinal epigenome-wide association study of preeclamptic and normotensive pregnancy.

Liu S, Fu H, Ray M, Heinsberg L, Conley Y, Anderson C Epigenetics Commun. 2023; 3(1).

PMID: 37063698 PMC: 10101051. DOI: 10.1186/s43682-022-00014-w.

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