Endocardial Left Ventricular Pacing

Overview

Journal Herz

Specialty Cardiology & Vascular Diseases

Date 2021 Oct 25

PMID 34694427

Authors

Mark K Elliott

Vishal S Mehta

Baldeep Singh Sidhu

Steven Niederer

Christopher A Rinaldi

Affiliations

Soon will be listed here.

Abstract

Cardiac resynchronization therapy (CRT) is an effective treatment for dyssynchronous heart failure; however, 30-50% of patients fail to improve after implant. Endocardial left ventricular (LV) pacing is an alternative therapy for patients who do not respond to conventional CRT or in whom placement of a lead via the coronary sinus is not possible. It enables pacing at a wide variety of sites, without restrictions due to coronary sinus anatomy, and there is evidence of superior electrical resynchronization and hemodynamic response compared with conventional epicardial CRT. In this article, we discuss the potential advantages and disadvantages of endocardial LV pacing compared with conventional CRT, review the evidence for the delivery of endocardial LV pacing using both lead-based and leadless systems, and explore possible future directions of this novel technology.

Citing Articles

Observational Study of Trans-Septal Endocardial Left Ventricle Lead Implant for Effective Cardiac Resynchronization Therapy in Patients with Heart Failure and Challenging Coronary Sinus Anatomy.

Farhangee A, Davies M, Gaughan K, Mesina M, Mindrila I Biomedicines. 2025; 12(12.

PMID: 39767600 PMC: 11673049. DOI: 10.3390/biomedicines12122693.

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