Oscillospira - a Candidate for the Next-generation Probiotics

Overview

Journal Gut Microbes

Specialties Gastroenterology
Microbiology

Date 2021 Oct 25

PMID 34693878

Citations 144

Authors

Jingpeng Yang

Yanan Li

Zhiqiang Wen

Wenzheng Liu

Lingtong Meng

He Huang

Affiliations

Soon will be listed here.

Abstract

is a class of organism that often appears in high-throughput sequencing data but has not been purely cultured and is widely present in the animal and human intestines. There is a strong association between variation in abundance and obesity, leanness, and human health. In addition, a growing body of studies has shown that is also implicated in other diseases, such as gallstones and chronic constipation, and has shown some correlation with the positive or negative changes in its course. Sequencing data combined with metabolic profiling indicate that is likely to be a genus capable of producing short-chain fatty acids (SCFAs) such as butyrate, which is an important reference indicator for screening "next-generation probiotics ". Considering the positive effects of in some specific diseases, such as obesity-related metabolic diseases, it has already been characterized as one of the next-generation probiotic candidates and therefore has great potential for development and application in the future food, health care, and biopharmaceutical products.

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