LncRNA DSCAM-AS1 Facilitates the Progression of Endometrial Cancer Via MiR-136-5p

Overview

Journal Oncol Lett

Specialty Oncology

Date 2021 Oct 25

PMID 34691252

Citations 11

Authors

Luhong Li

Peipei Chen

Bingbing Huang

Peiya Cai

Affiliations

Soon will be listed here.

Abstract

Previous studies have indicated that long non-coding RNA (lncRNA) down syndrome cell adhesion molecule antisense 1 (DSCAM-AS1) serves an oncogenic role in numerous cancer types. However, its role in endometrial cancer (EC) remains largely unknown. In the present study, DSCAM-AS1 expression levels in EC tissues and cells and their normal counterparts were analyzed using reverse transcription-quantitative. and experiments were conducted to validate the functions of DSCAM-AS1 in EC. It was revealed that DSCAM-AS1 was expressed at a high level in EC tissues and cells after analyzing patient data and data obtained from The Cancer Genome Atlas. Notably, it was also revealed that high DSCAM-AS1 expression was associated with a less favorable overall survival in patients with EC. Knockdown of DSCAM-AS1 was able to suppress EC cell proliferation by upregulating cell apoptosis . Furthermore, it was revealed that DSCAM-AS1 acted as a microRNA (miR)-136-5p sponge to exert its oncogenic roles in EC. Collectively and to the best of our knowledge, the current results provided first evidence that DSCAM-AS1 stimulated EC progression by regulating miR-136-5p, which may improve the understanding of the roles of ncRNAs in EC, and may help identify novel targets for anticancer treatment.

Citing Articles

The Promotive and Inhibitory Role of Long Non-Coding RNAs in Endometrial Cancer Course-A Review.

Jasielski P, Zawlik I, Bogaczyk A, Potocka N, Paszek S, Mazniak M Cancers (Basel). 2024; 16(11).

PMID: 38893244 PMC: 11171405. DOI: 10.3390/cancers16112125.

DSCAM-AS1 promotes the development of prostate cancer.

Cheng L, Li S, Jiang D, Zhang J Discov Oncol. 2024; 15(1):113.

PMID: 38605206 PMC: 11009176. DOI: 10.1007/s12672-024-00931-3.

LncRNA linc01194 promotes the progress of endometrial carcinoma by up-regulating SOX2 through binding to IGF2BP1.

Huang Z, Shen F, Chen J, Xie B, Chen X, Zhao Y J Gynecol Oncol. 2023; 35(2):e21.

PMID: 38072399 PMC: 10948988. DOI: 10.3802/jgo.2024.35.e21.

Editorial: The role of transcription factors, stem cell markers and epigenetics contributing to chemoresistance in brain cancers.

Castresana J, Shahi M, Sharma A Front Oncol. 2023; 13:1263469.

PMID: 37727217 PMC: 10505812. DOI: 10.3389/fonc.2023.1263469.

Deciphering the mechanisms of action of progesterone in breast cancer.

Chakravorty G, Ahmad S, Godbole M, Gupta S, Badwe R, Dutt A Oncotarget. 2023; 14:660-667.

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References

Qiu Z, Pan X, You D . LncRNA DSCAM-AS1 promotes non-small cell lung cancer progression via regulating miR-577/HMGB1 axis. Neoplasma. 2020; 67(4):871-879. DOI: 10.4149/neo_2020_190826N821. View

Raffone A, Travaglino A, Saccone G, Di Maio A, Mollo A, Mascolo M . Diabetes mellitus and responsiveness of endometrial hyperplasia and early endometrial cancer to conservative treatment. Gynecol Endocrinol. 2019; 35(11):932-937. DOI: 10.1080/09513590.2019.1624716. View

Liang J, Zhang S, Wang W, Xu Y, Kawuli A, Lu J . Long non-coding RNA DSCAM-AS1 contributes to the tumorigenesis of cervical cancer by targeting miR-877-5p/ATXN7L3 axis. Biosci Rep. 2019; 40(1). PMC: 6944662. DOI: 10.1042/BSR20192061. View

Kondo Y, Shinjo K, Katsushima K . Long non-coding RNAs as an epigenetic regulator in human cancers. Cancer Sci. 2017; 108(10):1927-1933. PMC: 5623749. DOI: 10.1111/cas.13342. View

Tang D, Zhao X, Zhang L, Wang C . Comprehensive analysis of pseudogene HSPB1P1 and its potential roles in hepatocellular carcinoma. J Cell Physiol. 2020; 235(10):6515-6527. DOI: 10.1002/jcp.29459. View

. An integrated encyclopedia of DNA elements in the human genome. Nature. 2012; 489(7414):57-74. PMC: 3439153. DOI: 10.1038/nature11247. View

Han C, Fu Y, Zeng N, Yin J, Li Q . LncRNA FAM83H-AS1 promotes triple-negative breast cancer progression by regulating the miR-136-5p/metadherin axis. Aging (Albany NY). 2020; 12(4):3594-3616. PMC: 7066879. DOI: 10.18632/aging.102832. View

Yang X, Hao Y, Wang B, Gu X, Wang X, Sun J . Long noncoding RNA NORAD promotes the progression of retinoblastoma by sponging miR 136-5p/PBX3 axis. Eur Rev Med Pharmacol Sci. 2020; 24(8):4055. DOI: 10.26355/eurrev_202004_20973. View

Zhao X, Tang D, Zuo X, Zhang T, Wang C . Identification of lncRNA-miRNA-mRNA regulatory network associated with epithelial ovarian cancer cisplatin-resistant. J Cell Physiol. 2019; 234(11):19886-19894. DOI: 10.1002/jcp.28587. View

10.

Li J, Huang C, Zou Y, Ye J, Yu J, Gui Y . CircTLK1 promotes the proliferation and metastasis of renal cell carcinoma by sponging miR-136-5p. Mol Cancer. 2020; 19(1):103. PMC: 7275467. DOI: 10.1186/s12943-020-01225-2. View

11.

Bray F, Ferlay J, Soerjomataram I, Siegel R, Torre L, Jemal A . Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018; 68(6):394-424. DOI: 10.3322/caac.21492. View

12.

Li B, Sun H, Zhang J . LncRNA DSCAM-AS1 promotes colorectal cancer progression by acting as a molecular sponge of miR-384 to modulate AKT3 expression. Aging (Albany NY). 2020; 12(10):9781-9792. PMC: 7288937. DOI: 10.18632/aging.103243. View

13.

Grixti J, Ayers D . Long noncoding RNAs and their link to cancer. Noncoding RNA Res. 2020; 5(2):77-82. PMC: 7256057. DOI: 10.1016/j.ncrna.2020.04.003. View

14.

Smith D, Stewart C, Clarke E, Lose F, Davies C, Armes J . ER and PR expression and survival after endometrial cancer. Gynecol Oncol. 2017; 148(2):258-266. DOI: 10.1016/j.ygyno.2017.11.027. View

15.

Zhao J, Yang T, Li L . LncRNA FOXP4-AS1 Is Involved in Cervical Cancer Progression via Regulating miR-136-5p/CBX4 Axis. Onco Targets Ther. 2020; 13:2347-2355. PMC: 7094166. DOI: 10.2147/OTT.S241818. View

16.

Liang W, Li N, Yuan Z, Qian X, Wang Z . DSCAM-AS1 promotes tumor growth of breast cancer by reducing miR-204-5p and up-regulating RRM2. Mol Carcinog. 2018; 58(4):461-473. DOI: 10.1002/mc.22941. View

17.

Ryu Y, Kang S, Cho J, Yoon J, Park M . Lymphovascular invasion can be better than pathologic complete response to predict prognosis in breast cancer treated with neoadjuvant chemotherapy. Medicine (Baltimore). 2018; 97(30):e11647. PMC: 6078671. DOI: 10.1097/MD.0000000000011647. View

18.

Matias-Guiu X, Prat J . Molecular pathology of endometrial carcinoma. Histopathology. 2012; 62(1):111-23. DOI: 10.1111/his.12053. View

19.

Ji D, Hu G, Zhang X, Yu T, Yang J . Long non-coding RNA DSCAM-AS1 accelerates the progression of hepatocellular carcinoma via sponging miR-338-3p. Am J Transl Res. 2019; 11(7):4290-4302. PMC: 6684899. View

20.

Qu Y, Tan H, Chan Y, Jiang H, Wang N, Wang D . The functional role of long noncoding RNA in resistance to anticancer treatment. Ther Adv Med Oncol. 2020; 12:1758835920927850. PMC: 7268113. DOI: 10.1177/1758835920927850. View