Long Non-coding RNA DSCAM-AS1 Contributes to the Tumorigenesis of Cervical Cancer by Targeting MiR-877-5p/ATXN7L3 Axis

Overview

Journal Biosci Rep

Specialty Cell Biology

Date 2019 Nov 19

PMID 31737900

Citations 28

Authors

Jie Liang

Shujuan Zhang

Wei Wang

Yan Xu

Atikan Kawuli

Jiaqi Lu

Xuemei Xiu

Affiliations

Soon will be listed here.

Abstract

Cervical cancer (CC) is ranked as the fourth most common cancer that occurs in women universally, which normally causes pain in the lower belly. Plenty of studies have stated that the expression of long non-coding RNAs (lncRNAs) is linked to the cellular development of many kinds of cancers. DSCAM-AS1 has been reported to act as an oncogene in other cancer types and the aim of our study was to uncover the function and regulatory mechanism of DSCAM-AS1 in CC. In this research, our findings presented that DSCAM-AS1 expression was up-regulated in CC cells. DSCAM-AS1 led to the development of CC by enhancing cell proliferation, migration and invasion ability. DSCAM-AS1 was verified to combine with miR-877-5p and down-regulate the expression of miR-877-5p. Results also showed that ATXN7L3 was a downstream target gene of miR-877-5p and it was unfavorably modulated by miR-877-5p. Enhanced expression of ATXN7L3 counterbalanced the DSCAM-AS1 knockdown effect on the progression of CC. This was the first time to analyze the underlying regulatory mechanism of the oncogenic DSCAM-AS1. Our findings clarified that DSCAM-AS1 played as an oncogenic lncRNA by targeting miR-877-5p/ATXN7L3 axis to promote CC progression, which may provide insights into the prevention of CC.

Citing Articles

Therapeutic Landscape of FOXM1 in Triple-Negative Breast Cancer and Aggressive Solid Cancers.

Dilmac S, Hamurcu Z, Ozpolat B Cancers (Basel). 2024; 16(22).

PMID: 39594778 PMC: 11593102. DOI: 10.3390/cancers16223823.

circ_0039787 promotes cervical cancer cell tumorigenesis by regulation of the miR-877-5p-KRAS axis.

He X, Sun J, Zhang J, Zhu B, Jin L, Wang J Aging (Albany NY). 2024; 16(3):2736-2752.

PMID: 38309290 PMC: 10911348. DOI: 10.18632/aging.205508.

A Comprehensive Study on Signal Transduction and Therapeutic Role of miR-877 in Human Cancers.

Rafat M, Kohsarian M, Bahiraei M, Nikpoor A Adv Biomed Res. 2023; 12:118.

PMID: 37434921 PMC: 10331537. DOI: 10.4103/abr.abr_412_21.

Long non‑coding RNA DSCAM‑AS1 functions as an oncogene in thyroid cancer via regulating miR‑211.

Hua T, Yang J, Zhu Y, Luo Y Oncol Lett. 2023; 25(4):165.

PMID: 36960191 PMC: 10028226. DOI: 10.3892/ol.2023.13752.

Long Noncoding RNA DSCAM-AS1 Facilitates Proliferation and Migration of Hemangioma Endothelial Cells by Targeting miR-411-5p/TPD52 Axis.

Wang Y, Zhai S, Xing J, Zhang J, He Y, Wang G Biomed Res Int. 2022; 2022:8696432.

PMID: 36267843 PMC: 9578823. DOI: 10.1155/2022/8696432.

References

Pan L, Chen H, Bai Y, Wang Q, Chen L . Long non-coding RNA CASC2 serves as a ceRNA of microRNA-21 to promote PDCD4 expression in oral squamous cell carcinoma. Onco Targets Ther. 2019; 12:3377-3385. PMC: 6510394. DOI: 10.2147/OTT.S198970. View

Wu Q, Zheng B, Weng G, Yang H, Ren Y, Weng X . Downregulated NOX4 underlies a novel inhibitory role of microRNA-137 in prostate cancer. J Cell Biochem. 2019; 120(6):10215-10227. DOI: 10.1002/jcb.28306. View

Xu Y, Zhou W, Zhang C, Liu X, Lv J, Li X . Long non-coding RNA RP11-552M11.4 favors tumorigenesis and development of cervical cancer via modulating miR-3941/ATF1 signaling. Int J Biol Macromol. 2019; 130:24-33. DOI: 10.1016/j.ijbiomac.2019.02.083. View

Chang S, Woo J, Yau V, Gorzalka B, Brotto L . Cervical cancer screening and chinese women: insights from focus groups. Front Psychol. 2013; 4:48. PMC: 3573354. DOI: 10.3389/fpsyg.2013.00048. View

Liu K, Liu C, Zhang Z . lncRNA GAS5 acts as a ceRNA for miR-21 in suppressing PDGF-bb-induced proliferation and migration in vascular smooth muscle cells. J Cell Biochem. 2019; 120(9):15233-15240. DOI: 10.1002/jcb.28789. View

Li Y, Hao J, Jiang Y, Liu Y, Zhang S . Long non-coding RNA DSCAM-AS1 indicates a poor prognosis and modulates cell proliferation, migration and invasion in ovarian cancer via upregulating SOX4. Eur Rev Med Pharmacol Sci. 2019; 23(10):4143-4148. DOI: 10.26355/eurrev_201905_17916. View

Park S, Eom K, Kim J, Bang H, Wang H, Ahn S . MiR-9, miR-21, and miR-155 as potential biomarkers for HPV positive and negative cervical cancer. BMC Cancer. 2017; 17(1):658. PMC: 5609051. DOI: 10.1186/s12885-017-3642-5. View

Shrestha A, Neupane D, Vedsted P, Kallestrup P . Cervical Cancer Prevalence, Incidence and Mortality in Low and Middle Income Countries: A Systematic Review. Asian Pac J Cancer Prev. 2018; 19(2):319-324. PMC: 5980914. DOI: 10.22034/APJCP.2018.19.2.319. View

Yan T, Qiu C, Sun J, Li W . MiR-877-5p suppresses cell growth, migration and invasion by targeting cyclin dependent kinase 14 and predicts prognosis in hepatocellular carcinoma. Eur Rev Med Pharmacol Sci. 2018; 22(10):3038-3046. DOI: 10.26355/eurrev_201805_15061. View

10.

Wan W, Hou Y, Wang K, Cheng Y, Pu X, Ye X . The LXR-623-induced long non-coding RNA LINC01125 suppresses the proliferation of breast cancer cells via PTEN/AKT/p53 signaling pathway. Cell Death Dis. 2019; 10(3):248. PMC: 6416354. DOI: 10.1038/s41419-019-1440-5. View

11.

Shan S, Li H, Yang X, Guo S, Guo Y, Chu L . Higher lncRNA CASC15 expression predicts poor prognosis and associates with tumor growth in cervical cancer. Eur Rev Med Pharmacol Sci. 2019; 23(2):507-512. DOI: 10.26355/eurrev_201901_16862. View

12.

Ai X, Lei Q, Shen X, Li J, Cen C, Xie G . Long non‑coding RNA ENST00000547547 inhibits cell proliferation, invasion and migration in colorectal cancer cells. Oncol Rep. 2018; 41(1):483-491. DOI: 10.3892/or.2018.6834. View

13.

Zhang X, Zhao X, Li Y, Zhou Y, Zhang Z . Long noncoding RNA SOX21-AS1 promotes cervical cancer progression by competitively sponging miR-7/VDAC1. J Cell Physiol. 2019; 234(10):17494-17504. DOI: 10.1002/jcp.28371. View

14.

Liao J, Xie N . Long noncoding RNA DSCAM-AS1 functions as an oncogene in non-small cell lung cancer by targeting BCL11A. Eur Rev Med Pharmacol Sci. 2019; 23(3):1087-1092. DOI: 10.26355/eurrev_201902_16998. View

15.

Liang W, Li N, Yuan Z, Qian X, Wang Z . DSCAM-AS1 promotes tumor growth of breast cancer by reducing miR-204-5p and up-regulating RRM2. Mol Carcinog. 2018; 58(4):461-473. DOI: 10.1002/mc.22941. View

16.

Ji F, Wuerkenbieke D, He Y, Ding Y, Du R . Long Noncoding RNA HOTAIR: An Oncogene in Human Cervical Cancer Interacting With MicroRNA-17-5p. Oncol Res. 2017; 26(3):353-361. PMC: 7844841. DOI: 10.3727/096504017X15002869385155. View

17.

Kong X, Qi J, Yan Y, Chen L, Zhao Y, Fang Z . Comprehensive analysis of differentially expressed profiles of lncRNAs, mRNAs, and miRNAs in laryngeal squamous cell carcinoma in order to construct a ceRNA network and identify potential biomarkers. J Cell Biochem. 2019; 120(10):17963-17974. DOI: 10.1002/jcb.29063. View

18.

Xie J, Guo Q, Jin J, Jin D . SP1-mediated overexpression of lncRNA LINC01234 as a ceRNA facilitates non-small-cell lung cancer progression via regulating OTUB1. J Cell Physiol. 2019; 234(12):22845-22856. DOI: 10.1002/jcp.28848. View

19.

Ferlay J, Forman D, Mathers C, Bray F . Breast and cervical cancer in 187 countries between 1980 and 2010. Lancet. 2012; 379(9824):1390-1. DOI: 10.1016/S0140-6736(12)60595-9. View

20.

Huang Y, Xu Q, Wang X . Long noncoding RNA DSCAM-AS1 is associated with poor clinical prognosis and contributes to melanoma development by sponging miR-136. Eur Rev Med Pharmacol Sci. 2019; 23(7):2888-2897. DOI: 10.26355/eurrev_201904_17567. View