Recent Advances in Cardiac Tissue Engineering for the Management of Myocardium Infarction

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2021 Oct 23

PMID 34685518

Citations 13

Authors

Vineeta Sharma

Sanat Kumar Dash

Kavitha Govarthanan

Rekha Gahtori

Nidhi Negi

Mahmood Barani

Richa Tomar

Sudip Chakraborty

Santosh Mathapati

Dillip Kumar Bishi

Poonam Negi

Kamal Dua

Sachin Kumar Singh

Rohit Gundamaraju

Abhijit Dey

Janne Ruokolainen

Vijay Kumar Thakur

Kavindra Kumar Kesari

Niraj Kumar Jha

Piyush Kumar Gupta

Shreesh Ojha

Affiliations

Soon will be listed here.

Abstract

Myocardium Infarction (MI) is one of the foremost cardiovascular diseases (CVDs) causing death worldwide, and its case numbers are expected to continuously increase in the coming years. Pharmacological interventions have not been at the forefront in ameliorating MI-related morbidity and mortality. Stem cell-based tissue engineering approaches have been extensively explored for their regenerative potential in the infarcted myocardium. Recent studies on microfluidic devices employing stem cells under laboratory set-up have revealed meticulous events pertaining to the pathophysiology of MI occurring at the infarcted site. This discovery also underpins the appropriate conditions in the niche for differentiating stem cells into mature cardiomyocyte-like cells and leads to engineering of the scaffold via mimicking of native cardiac physiological conditions. However, the mode of stem cell-loaded engineered scaffolds delivered to the site of infarction is still a challenging mission, and yet to be translated to the clinical setting. In this review, we have elucidated the various strategies developed using a hydrogel-based system both as encapsulated stem cells and as biocompatible patches loaded with cells and applied at the site of infarction.

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References

Chow A, Stuckey D, Kidher E, Rocco M, Jabbour R, Mansfield C . Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Encapsulating Bioactive Hydrogels Improve Rat Heart Function Post Myocardial Infarction. Stem Cell Reports. 2017; 9(5):1415-1422. PMC: 5830963. DOI: 10.1016/j.stemcr.2017.09.003. View

Esmaeili R, Darbandi-Azar A, Sadeghpour A, Majidzadeh-A K, Eini L, Jafarbeik-Iravani N . Mesenchymal Stem Cells Pretreatment With Stromal-Derived Factor-1 Alpha Augments Cardiac Function and Angiogenesis in Infarcted Myocardium. Am J Med Sci. 2021; 361(6):765-775. DOI: 10.1016/j.amjms.2021.01.025. View

Jeffords M, Wu J, Shah M, Hong Y, Zhang G . Tailoring material properties of cardiac matrix hydrogels to induce endothelial differentiation of human mesenchymal stem cells. ACS Appl Mater Interfaces. 2015; 7(20):11053-61. PMC: 4684185. DOI: 10.1021/acsami.5b03195. View

Kuraitis D, Giordano C, Ruel M, Musaro A, Suuronen E . Exploiting extracellular matrix-stem cell interactions: a review of natural materials for therapeutic muscle regeneration. Biomaterials. 2011; 33(2):428-43. DOI: 10.1016/j.biomaterials.2011.09.078. View

Fleischer S, Feiner R, Dvir T . Cutting-edge platforms in cardiac tissue engineering. Curr Opin Biotechnol. 2017; 47:23-29. DOI: 10.1016/j.copbio.2017.05.008. View

Stout D, Basu B, Webster T . RETRACTED: Poly(lactic-co-glycolic acid): carbon nanofiber composites for myocardial tissue engineering applications. Acta Biomater. 2011; 7(8):3101-12. DOI: 10.1016/j.actbio.2011.04.028. View

Miao C, Lei M, Hu W, Han S, Wang Q . A brief review: the therapeutic potential of bone marrow mesenchymal stem cells in myocardial infarction. Stem Cell Res Ther. 2017; 8(1):242. PMC: 5667518. DOI: 10.1186/s13287-017-0697-9. View

Li Y, Meng H, Liu Y, Lee B . Fibrin gel as an injectable biodegradable scaffold and cell carrier for tissue engineering. ScientificWorldJournal. 2015; 2015:685690. PMC: 4380102. DOI: 10.1155/2015/685690. View

Hasan A, Khattab A, Islam M, Hweij K, Zeitouny J, Waters R . Injectable Hydrogels for Cardiac Tissue Repair after Myocardial Infarction. Adv Sci (Weinh). 2016; 2(11):1500122. PMC: 5033116. DOI: 10.1002/advs.201500122. View

10.

Dong R, Zhao X, Guo B, Ma P . Self-Healing Conductive Injectable Hydrogels with Antibacterial Activity as Cell Delivery Carrier for Cardiac Cell Therapy. ACS Appl Mater Interfaces. 2016; 8(27):17138-50. DOI: 10.1021/acsami.6b04911. View

11.

Sun H, Zhou J, Huang Z, Qu L, Lin N, Liang C . Carbon nanotube-incorporated collagen hydrogels improve cell alignment and the performance of cardiac constructs. Int J Nanomedicine. 2017; 12:3109-3120. PMC: 5399986. DOI: 10.2147/IJN.S128030. View

12.

Toma C, Pittenger M, Cahill K, Byrne B, Kessler P . Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation. 2002; 105(1):93-8. DOI: 10.1161/hc0102.101442. View

13.

Timmis A, Townsend N, Gale C, Torbica A, Lettino M, Petersen S . European Society of Cardiology: Cardiovascular Disease Statistics 2019. Eur Heart J. 2019; 41(1):12-85. DOI: 10.1093/eurheartj/ehz859. View

14.

Wu J, Dong M, Santos S, Rigatto C, Liu Y, Lin F . Lab-on-a-Chip Platforms for Detection of Cardiovascular Disease and Cancer Biomarkers. Sensors (Basel). 2017; 17(12). PMC: 5751502. DOI: 10.3390/s17122934. View

15.

Kobayashi K, Ichihara Y, Sato N, Umeda N, Fields L, Fukumitsu M . On-site fabrication of Bi-layered adhesive mesenchymal stromal cell-dressings for the treatment of heart failure. Biomaterials. 2019; 209:41-53. PMC: 6527869. DOI: 10.1016/j.biomaterials.2019.04.014. View

16.

Bai R, Tian L, Li Y, Zhang J, Wei Y, Jin Z . Combining ECM Hydrogels of Cardiac Bioactivity with Stem Cells of High Cardiomyogenic Potential for Myocardial Repair. Stem Cells Int. 2019; 2019:6708435. PMC: 6854924. DOI: 10.1155/2019/6708435. View

17.

Nemcovsky Amar D, Epshtein M, Korin N . Endothelial Cell Activation in an Embolic Ischemia-Reperfusion Injury Microfluidic Model. Micromachines (Basel). 2019; 10(12). PMC: 6952880. DOI: 10.3390/mi10120857. View

18.

Fang J, Koh J, Fang Q, Qiu H, Archang M, Hasani-Sadrabadi M . Injectable Drug-Releasing Microporous Annealed Particle Scaffolds for Treating Myocardial Infarction. Adv Funct Mater. 2021; 30(43). PMC: 7942842. DOI: 10.1002/adfm.202004307. View

19.

Kanda P, Benavente-Babace A, Parent S, Connor M, Soucy N, Steeves A . Deterministic paracrine repair of injured myocardium using microfluidic-based cocooning of heart explant-derived cells. Biomaterials. 2020; 247:120010. DOI: 10.1016/j.biomaterials.2020.120010. View

20.

Piao H, Kwon J, Piao S, Sohn J, Lee Y, Bae J . Effects of cardiac patches engineered with bone marrow-derived mononuclear cells and PGCL scaffolds in a rat myocardial infarction model. Biomaterials. 2006; 28(4):641-9. DOI: 10.1016/j.biomaterials.2006.09.009. View