3D-Printed Mucoadhesive Collagen Scaffolds As a Local Tetrahydrocurcumin Delivery System

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2021 Oct 23

PMID 34683989

Citations 1

Authors

Mireia Andonegi

Teresa Carranza

Alaitz Etxabide

Koro de la Caba

Pedro Guerrero

Affiliations

Soon will be listed here.

Abstract

Native collagen doughs were processed using a syringe-based extrusion 3D printer to obtain collagen scaffolds. Before processing, the rheological properties of the doughs were analyzed to determine the optimal 3D printing conditions. Samples showed a high shear-thinning behavior, reported beneficial in the 3D printing process. In addition, tetrahydrocurcumin (THC) was incorporated into the dough formulation and its effect on collagen structure, as well as the resulting scaffold's suitability for wound healing applications, were assessed. The denaturation peak observed by differential scanning calorimetry (DSC), along with the images of the scaffolds' surfaces assessed using scanning electron microscopy (SEM), showed that the fibrillar structure of collagen was maintained. These outcomes were correlated with X-ray diffraction (XRD) results, which showed an increase of the lateral packaging of collagen chains was observed in the samples with a THC content up to 4%, while a higher content of THC considerably decreased the structural order of collagen. Furthermore, physical interactions between collagen and THC molecules were observed using Fourier transform infrared (FTIR) spectroscopy. Additionally, all samples showed swelling and a controlled release of THC. These results along with the mucoadhesive properties of collagen suggested the potential of these THC-collagen scaffolds as sustained THC delivery systems.

Citing Articles

The anticancer potential of tetrahydrocurcumin-phytosomes against oral carcinoma progression.

Raouf N, Darwish Z, Ramadan O, Barakat H, Elbanna S, Essawy M BMC Oral Health. 2024; 24(1):1126.

PMID: 39327561 PMC: 11430579. DOI: 10.1186/s12903-024-04856-9.

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