Utilising Co-Axial Electrospinning As a Taste-Masking Technology for Paediatric Drug Delivery

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2021 Oct 23

PMID 34683958

Citations 9

Authors

Hend E Abdelhakim

Alastair Coupe

Catherine Tuleu

Mohan Edirisinghe

Duncan Q M Craig

Affiliations

Soon will be listed here.

Abstract

The present study describes the use of two taste-masking polymers to fabricate a formulation of chlorpheniramine maleate for paediatric administration. Co-axial electrospinning was utilized to create layered nanofibres; the two polymers, Eudragit E PO and Kollicoat Smartseal, were alternated between the core and the shell of the system in order to identify the optimum taste-masked formulation. The drug was loaded in the core on all occasions. It was found that the formulation with Kollicoat Smartseal in the core with the drug, and Eudragit E PO in the shell showed the most effective taste-masking compared to the other formulations. These fibres were in the nano-range and had smooth morphology as verified by scanning electron microscopy. Solid-state characterization and thermal analysis confirmed that amorphous solid dispersions were formed upon electrospinning. The Insent E-tongue was used to assess the taste-masking efficiency of the samples, and it was found that this formulation was undetectable by the bitter sensor, indicating successful taste-masking compared to the raw version of the drug. The E-tongue also confirmed the drug's bitterness threshold as compared to quinine HCl dihydrate, a parameter that is useful for formulation design and taste-masking planning.

Citing Articles

Delivery of TGFβ3 from Magnetically Responsive Coaxial Fibers Reduces Spinal Cord Astrocyte Reactivity In Vitro.

Funnell J, Fougere J, Zahn D, Dutz S, Gilbert R Adv Biol (Weinh). 2024; 8(10):e2300531.

PMID: 38935534 PMC: 11473240. DOI: 10.1002/adbi.202300531.

Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients.

Steiner D, Meyer A, Immohr L, Pein-Hackelbusch M Pharmaceutics. 2024; 16(5).

PMID: 38794320 PMC: 11125162. DOI: 10.3390/pharmaceutics16050658.

The Study of Amorphous Kaempferol Dispersions Involving FT-IR Spectroscopy.

Rosiak N, Tykarska E, Cielecka-Piontek J Int J Mol Sci. 2023; 24(24).

PMID: 38138984 PMC: 10742969. DOI: 10.3390/ijms242417155.

Electrospun Nanofibers: Shaping the Future of Controlled and Responsive Drug Delivery.

Wildy M, Lu P Materials (Basel). 2023; 16(22).

PMID: 38004992 PMC: 10672065. DOI: 10.3390/ma16227062.

Tri-Layer Core-Shell Fibers from Coaxial Electrospinning for a Modified Release of Metronidazole.

Wang Y, Liu L, Zhu Y, Wang L, Yu D, Liu L Pharmaceutics. 2023; 15(11).

PMID: 38004540 PMC: 10674365. DOI: 10.3390/pharmaceutics15112561.

References

Illangakoon U, Gill H, Shearman G, Parhizkar M, Mahalingam S, Chatterton N . Fast dissolving paracetamol/caffeine nanofibers prepared by electrospinning. Int J Pharm. 2014; 477(1-2):369-79. DOI: 10.1016/j.ijpharm.2014.10.036. View

Melis M, Aragoni M, Arca M, Cabras T, Caltagirone C, Castagnola M . Marked increase in PROP taste responsiveness following oral supplementation with selected salivary proteins or their related free amino acids. PLoS One. 2013; 8(3):e59810. PMC: 3610910. DOI: 10.1371/journal.pone.0059810. View

Pein M, Preis M, Eckert C, Kiene F . Taste-masking assessment of solid oral dosage forms--a critical review. Int J Pharm. 2014; 465(1-2):239-54. DOI: 10.1016/j.ijpharm.2014.01.036. View

Sill T, von Recum H . Electrospinning: applications in drug delivery and tissue engineering. Biomaterials. 2008; 29(13):1989-2006. DOI: 10.1016/j.biomaterials.2008.01.011. View

Vrbata P, Berka P, Stranska D, Dolezal P, Musilova M, cizinska L . Electrospun drug loaded membranes for sublingual administration of sumatriptan and naproxen. Int J Pharm. 2013; 457(1):168-76. DOI: 10.1016/j.ijpharm.2013.08.085. View

Vass P, Szabo E, Domokos A, Hirsch E, Galata D, Farkas B . Scale-up of electrospinning technology: Applications in the pharmaceutical industry. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2019; 12(4):e1611. DOI: 10.1002/wnan.1611. View

Jia D, Gao Y, Williams G . Core/shell poly(ethylene oxide)/Eudragit fibers for site-specific release. Int J Pharm. 2017; 523(1):376-385. DOI: 10.1016/j.ijpharm.2017.03.038. View

Turner M, Catapano M, Hirschfeld S, Giaquinto C . Paediatric drug development: the impact of evolving regulations. Adv Drug Deliv Rev. 2014; 73:2-13. DOI: 10.1016/j.addr.2014.02.003. View

Keating A, Soto J, Forbes C, Zhao M, Craig D, Tuleu C . Multi-Methodological Quantitative Taste Assessment of Anti-Tuberculosis Drugs to Support the Development of Palatable Paediatric Dosage Forms. Pharmaceutics. 2020; 12(4). PMC: 7238065. DOI: 10.3390/pharmaceutics12040369. View

10.

Keating A, Soto J, Tuleu C, Forbes C, Zhao M, Craig D . Solid state characterisation and taste masking efficiency evaluation of polymer based extrudates of isoniazid for paediatric administration. Int J Pharm. 2017; 536(2):536-546. DOI: 10.1016/j.ijpharm.2017.07.008. View

11.

Tian Y, Orlu M, Woerdenbag H, Scarpa M, Kiefer O, Kottke D . Oromucosal films: from patient centricity to production by printing techniques. Expert Opin Drug Deliv. 2019; 16(9):981-993. DOI: 10.1080/17425247.2019.1652595. View

12.

Abdelhakim H, Williams G, Craig D, Orlu M, Tuleu C . Human mouthfeel panel investigating the acceptability of electrospun and solvent cast orodispersible films. Int J Pharm. 2020; 585:119532. DOI: 10.1016/j.ijpharm.2020.119532. View

13.

Slavkova M, Breitkreutz J . Orodispersible drug formulations for children and elderly. Eur J Pharm Sci. 2015; 75:2-9. DOI: 10.1016/j.ejps.2015.02.015. View

14.

Tawfik E, Craig D, Barker S . Dual drug-loaded coaxial nanofibers for the treatment of corneal abrasion. Int J Pharm. 2020; 581:119296. DOI: 10.1016/j.ijpharm.2020.119296. View

15.

Keeley A, Teo M, Ali Z, Frost J, Ghimire M, Rajabi-Siahboomi A . In Vitro Dissolution Model Can Predict the in Vivo Taste Masking Performance of Coated Multiparticulates. Mol Pharm. 2019; 16(5):2095-2105. DOI: 10.1021/acs.molpharmaceut.9b00060. View

16.

Mohamed-Ahmed A, Soto J, Ernest T, Tuleu C . Non-human tools for the evaluation of bitter taste in the design and development of medicines: a systematic review. Drug Discov Today. 2016; 21(7):1170-80. DOI: 10.1016/j.drudis.2016.05.014. View

17.

Soto J, Keeley A, Keating A, Mohamed-Ahmed A, Sheng Y, Winzenburg G . Rats can predict aversiveness of Active Pharmaceutical Ingredients. Eur J Pharm Biopharm. 2018; 133:77-84. DOI: 10.1016/j.ejpb.2018.09.027. View

18.

Chay S, Keating A, James C, Aliev A, Haider S, Craig D . Evaluation of the taste-masking effects of (2-hydroxypropyl)-β-cyclodextrin on ranitidine hydrochloride; a combined biosensor, spectroscopic and molecular modelling assessment. RSC Adv. 2022; 8(7):3564-3573. PMC: 9077696. DOI: 10.1039/c7ra11015d. View

19.

Takeuchi Y, Usui R, Ikezaki H, Tahara K, Takeuchi H . An advanced technique using an electronic taste-sensing system to evaluate the bitterness of orally disintegrating films and the evaluation of model films. Int J Pharm. 2017; 531(1):179-190. DOI: 10.1016/j.ijpharm.2017.07.073. View

20.

Standing J, Tuleu C . Paediatric formulations--getting to the heart of the problem. Int J Pharm. 2005; 300(1-2):56-66. DOI: 10.1016/j.ijpharm.2005.05.006. View