Electrospun Nanofibers: Shaping the Future of Controlled and Responsive Drug Delivery

Overview

Journal Materials (Basel)

Publisher MDPI

Date 2023 Nov 25

PMID 38004992

Authors

Michael Wildy

Ping Lu

Affiliations

Soon will be listed here.

Abstract

Electrospun nanofibers for drug delivery systems (DDS) introduce a revolutionary means of administering pharmaceuticals, holding promise for both improved drug efficacy and reduced side effects. These biopolymer nanofiber membranes, distinguished by their high surface area-to-volume ratio, biocompatibility, and biodegradability, are ideally suited for pharmaceutical and biomedical applications. One of their standout attributes is the capability to offer the controlled release of the active pharmaceutical ingredient (API), allowing custom-tailored release profiles to address specific diseases and administration routes. Moreover, stimuli-responsive electrospun DDS can adapt to conditions at the drug target, enhancing the precision and selectivity of drug delivery. Such localized API delivery paves the way for superior therapeutic efficiency while diminishing the risk of side effects and systemic toxicity. Electrospun nanofibers can foster better patient compliance and enhanced clinical outcomes by amplifying the therapeutic efficiency of routinely prescribed medications. This review delves into the design principles and techniques central to achieving controlled API release using electrospun membranes. The advanced drug release mechanisms of electrospun DDS highlighted in this review illustrate their versatility and potential to improve the efficacy of medical treatments.

Citing Articles

Gum Arabic: A Commodity with Versatile Formulations and Applications.

Mohamed S, Elsherbini A, Alrefaey H, Adelrahman K, Moustafa A, Egodawaththa N Nanomaterials (Basel). 2025; 15(4).

PMID: 39997853 PMC: 11858195. DOI: 10.3390/nano15040290.

A systematic review of liposomal nanofibrous scaffolds as a drug delivery system: a decade of progress in controlled release and therapeutic efficacy.

Abboud H, Zelko R, Kazsoki A Drug Deliv. 2024; 32(1):2445259.

PMID: 39727310 PMC: 11703383. DOI: 10.1080/10717544.2024.2445259.

Nanomaterial-enabled drug transport systems: a comprehensive exploration of current developments and future avenues in therapeutic delivery.

Basu S, Biswas P, Anto M, Singh N, Mukherjee K 3 Biotech. 2024; 14(12):289.

PMID: 39507057 PMC: 11534931. DOI: 10.1007/s13205-024-04135-y.

Heat's Role in Solution Electrospinning: A Novel Approach to Nanofiber Structure Optimization.

Wildy M, Wei W, Xu K, Schossig J, Hu X, Hyun D Langmuir. 2024; 40(15):7982-7991.

PMID: 38569012 PMC: 11025124. DOI: 10.1021/acs.langmuir.3c03919.

References

Zech J, Mader M, Gundel D, Metz H, Odparlik A, Agarwal S . Noninvasive characterization (EPR, μCT, NMR) of 3D PLA electrospun fiber sponges for controlled drug delivery. Int J Pharm X. 2020; 2:100055. PMC: 7492987. DOI: 10.1016/j.ijpx.2020.100055. View

Lu H, Wang Q, Li G, Qiu Y, Wei Q . Electrospun water-stable zein/ethyl cellulose composite nanofiber and its drug release properties. Mater Sci Eng C Mater Biol Appl. 2017; 74:86-93. DOI: 10.1016/j.msec.2017.02.004. View

Sahana T, Rekha P . Biopolymers: Applications in wound healing and skin tissue engineering. Mol Biol Rep. 2018; 45(6):2857-2867. DOI: 10.1007/s11033-018-4296-3. View

Longley D, Harkin D, Johnston P . 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer. 2003; 3(5):330-8. DOI: 10.1038/nrc1074. View

Masek J, Lubasova D, Lukac R, Turanek-Knotigova P, Kulich P, Plockova J . Multi-layered nanofibrous mucoadhesive films for buccal and sublingual administration of drug-delivery and vaccination nanoparticles - important step towards effective mucosal vaccines. J Control Release. 2016; 249:183-195. DOI: 10.1016/j.jconrel.2016.07.036. View

Wali A, Gorain M, Inamdar S, Kundu G, Badiger M . In Vivo Wound Healing Performance of Halloysite Clay and Gentamicin-Incorporated Cellulose Ether-PVA Electrospun Nanofiber Mats. ACS Appl Bio Mater. 2022; 2(10):4324-4334. DOI: 10.1021/acsabm.9b00589. View

Wadhwa J, Nair A, Kumria R . Emulsion forming drug delivery system for lipophilic drugs. Acta Pol Pharm. 2012; 69(2):179-91. View

Chou S, Carson D, Woodrow K . Current strategies for sustaining drug release from electrospun nanofibers. J Control Release. 2015; 220(Pt B):584-91. PMC: 5235363. DOI: 10.1016/j.jconrel.2015.09.008. View

Abasalta M, Asefnejad A, Khorasani M, Ramazani Saadatabadi A . Fabrication of carboxymethyl chitosan/poly(ε-caprolactone)/doxorubicin/nickel ferrite core-shell fibers for controlled release of doxorubicin against breast cancer. Carbohydr Polym. 2021; 257:117631. DOI: 10.1016/j.carbpol.2021.117631. View

10.

Carvalho C, Santos R, Cardoso S, Correia S, Oliveira P, Santos M . Doxorubicin: the good, the bad and the ugly effect. Curr Med Chem. 2009; 16(25):3267-85. DOI: 10.2174/092986709788803312. View

11.

Jeong B, Bae Y, Kim S . Drug release from biodegradable injectable thermosensitive hydrogel of PEG-PLGA-PEG triblock copolymers. J Control Release. 2000; 63(1-2):155-63. DOI: 10.1016/s0168-3659(99)00194-7. View

12.

Godakanda V, Li H, Alquezar L, Zhao L, Zhu L, de Silva R . Tunable drug release from blend poly(vinyl pyrrolidone)-ethyl cellulose nanofibers. Int J Pharm. 2019; 562:172-179. DOI: 10.1016/j.ijpharm.2019.03.035. View

13.

Rasekh M, Karavasili C, Soong Y, Bouropoulos N, Morris M, Armitage D . Electrospun PVP-indomethacin constituents for transdermal dressings and drug delivery devices. Int J Pharm. 2014; 473(1-2):95-104. DOI: 10.1016/j.ijpharm.2014.06.059. View

14.

Tugcu-Demiroz F, Saar S, Tort S, Acarturk F . Electrospun metronidazole-loaded nanofibers for vaginal drug delivery. Drug Dev Ind Pharm. 2020; 46(6):1015-1025. DOI: 10.1080/03639045.2020.1767125. View

15.

Mao Z, Li J, Huang W, Jiang H, Zimba B, Chen L . Preparation of poly(lactic acid)/graphene oxide nanofiber membranes with different structures by electrospinning for drug delivery. RSC Adv. 2022; 8(30):16619-16625. PMC: 9080315. DOI: 10.1039/c8ra01565a. View

16.

Xue J, Wu T, Dai Y, Xia Y . Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications. Chem Rev. 2019; 119(8):5298-5415. PMC: 6589095. DOI: 10.1021/acs.chemrev.8b00593. View

17.

Yu D, Wang X, Li X, Chian W, Li Y, Liao Y . Electrospun biphasic drug release polyvinylpyrrolidone/ethyl cellulose core/sheath nanofibers. Acta Biomater. 2012; 9(3):5665-72. DOI: 10.1016/j.actbio.2012.10.021. View

18.

Yuan C, Long X, Li J, Cai Q . Coaxially electrospun 5-fluorouracil-loaded PLGA/PVP fibrous membrane for skin tumor treatment. Biomed Mater. 2021; 16(6). DOI: 10.1088/1748-605X/ac2887. View

19.

Moon G, Choi S, Cai X, Li W, Cho E, Jeong U . A new theranostic system based on gold nanocages and phase-change materials with unique features for photoacoustic imaging and controlled release. J Am Chem Soc. 2011; 133(13):4762-5. PMC: 3073071. DOI: 10.1021/ja200894u. View

20.

Xue J, Zhu C, Li J, Li H, Xia Y . Integration of Phase-Change Materials with Electrospun Fibers for Promoting Neurite Outgrowth under Controlled Release. Adv Funct Mater. 2019; 28(15). PMC: 6660177. DOI: 10.1002/adfm.201705563. View