Exosome Degeneration in Mesenchymal Stem Cells Derived from Patients with Type 1 Diabetes Mellitus

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Oct 23

PMID 34681566

Citations 8

Authors

Michiko Horiguchi

Yuko Okada

Yuya Turudome

Kentaro Ushijima

Affiliations

Soon will be listed here.

Abstract

Type 1 diabetes mellitus is characterized by the destruction of pancreatic β-cells and requires the regeneration of these destroyed pancreatic β-cells for radical treatment. The degeneration of organelles in stem cells compromises stem cell quality; however, organelles in the mesenchymal stem cells of patients with type 1 diabetes mellitus have not been characterized previously. In this study, we use transmission electron microscopy to evaluate the degeneration of organelles in adipose-derived stem cells of patients with type 1 diabetes mellitus (T1DM ADSCs). Compared to adipose-derived stem cells from healthy humans, T1DM ADSCs degenerate differently, characterized by prominent enlarged spherical vesicles. The exosomes of T1DM ADSCs are found to be enlarged, reduced in number, and increased in the percentage of those positive for tetraspanin CD9. The findings of this study provide insight into the characteristics of stem cells in patients with type 1 diabetes mellitus.

Citing Articles

The Diurnal Variation in Mitochondrial Gene in Human Type 2 Diabetic Mesenchymal Stem Cell Grafts.

Horiguchi M, Yoshihara K, Mizukami Y, Watanabe K, Tsurudome Y, Ushijima K Int J Mol Sci. 2025; 26(2.

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Exosomes in Autoimmune Diseases: A Review of Mechanisms and Diagnostic Applications.

Duan L, Lin W, Zhang Y, Jin L, Xiao J, Wang H Clin Rev Allergy Immunol. 2025; 68(1):5.

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Circadian Rhythms of Clock Genes After Transplantation of Mesenchymal Stem Cells with Type 2 Diabetes Mellitus.

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Apoptotic vesicles rescue impaired mesenchymal stem cells and their therapeutic capacity for osteoporosis by restoring miR-145a-5p deficiency.

Zhang R, Mu X, Liu D, Chen C, Meng B, Qu Y J Nanobiotechnology. 2024; 22(1):580.

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