Epigenetic Regulatory Dynamics in Models of Methamphetamine-Use Disorder

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2021 Oct 23

PMID 34681009

Citations 8

Authors

Subramaniam Jayanthi

Michael T McCoy

Jean Lud Cadet

Affiliations

Soon will be listed here.

Abstract

Methamphetamine (METH)-use disorder (MUD) is a very serious, potentially lethal, biopsychosocial disease. Exposure to METH causes long-term changes to brain regions involved in reward processing and motivation, leading vulnerable individuals to engage in pathological drug-seeking and drug-taking behavior that can remain a lifelong struggle. It is crucial to elucidate underlying mechanisms by which exposure to METH leads to molecular neuroadaptive changes at transcriptional and translational levels. Changes in gene expression are controlled by post-translational modifications via chromatin remodeling. This review article focuses on the brain-region specific combinatorial or distinct epigenetic modifications that lead to METH-induced changes in gene expression.

Citing Articles

An update: epigenetic mechanisms underlying methamphetamine addiction.

Liu M, Si Z Front Cell Dev Biol. 2024; 12:1494557.

PMID: 39650725 PMC: 11621221. DOI: 10.3389/fcell.2024.1494557.

Epigenome-wide association study on methamphetamine dependence.

Shirai T, Okazaki S, Tanifuji T, Otsuka I, Horai T, Mouri K Addict Biol. 2024; 29(3):e13383.

PMID: 38488760 PMC: 11061849. DOI: 10.1111/adb.13383.

Incubation of methamphetamine craving in punishment-resistant individuals is associated with activation of specific gene networks in the rat dorsal striatum.

Daiwile A, McCoy M, Ladenheim B, Subramaniam J, Cadet J Mol Psychiatry. 2024; 29(7):1990-2000.

PMID: 38351172 PMC: 11408252. DOI: 10.1038/s41380-024-02455-2.

Are We Getting High Cause the Thrill is Gone?.

Blum K, Mclaughlin T, Gold M, Gondre-Lewis M, Thanos P, Elman I J Addict Psychiatry. 2024; 7(1):5-516.

PMID: 38164471 PMC: 10758019.

Methamphetamine-induced region-specific transcriptomic and epigenetic changes in the brain of male rats.

Miao B, Xing X, Bazylianska V, Madden P, Moszczynska A, Zhang B Commun Biol. 2023; 6(1):991.

PMID: 37758941 PMC: 10533900. DOI: 10.1038/s42003-023-05355-3.

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