Environmental Alterations During Embryonic Development: Studying the Impact of Stressors on Pluripotent Stem Cell-Derived Cardiomyocytes

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2021 Oct 23

PMID 34680959

Citations 4

Authors

Federica Lamberto

Irene Peral-Sanchez

Suchitra Muenthaisong

Melinda Zana

Sandrine Willaime-Morawek

Andras Dinnyes

Affiliations

Soon will be listed here.

Abstract

Non-communicable diseases (NCDs) sauch as diabetes, obesity and cardiovascular diseases are rising rapidly in all countries world-wide. Environmental maternal factors (e.g., diet, oxidative stress, drugs and many others), maternal illnesses and other stressors can predispose the newborn to develop diseases during different stages of life. The connection between environmental factors and NCDs was formulated by David Barker and colleagues as the Developmental Origins of Health and Disease (DOHaD) hypothesis. In this review, we describe the DOHaD concept and the effects of several environmental stressors on the health of the progeny, providing both animal and human evidence. We focus on cardiovascular diseases which represent the leading cause of death worldwide. The purpose of this review is to discuss how in vitro studies with pluripotent stem cells (PSCs), such as embryonic and induced pluripotent stem cells (ESC, iPSC), can underpin the research on non-genetic heart conditions. The PSCs could provide a tool to recapitulate aspects of embryonic development "in a dish", studying the effects of environmental exposure during cardiomyocyte (CM) differentiation and maturation, establishing a link to molecular mechanism and epigenetics.

Citing Articles

Anomalous Blood Supply of the Superficial Face: A Case Report and Cadaveric Study of Facial and Transverse Facial Artery Variations.

Stucki B, Jones N, Judd D, Van Alfen B, Fowers R, Rosales A Cureus. 2025; 16(12):e75526.

PMID: 39803024 PMC: 11723774. DOI: 10.7759/cureus.75526.

The Current State of Realistic Heart Models for Disease Modelling and Cardiotoxicity.

Kistamas K, Lamberto F, Vaiciuleviciute R, Leal F, Muenthaisong S, Marte L Int J Mol Sci. 2024; 25(17).

PMID: 39273136 PMC: 11394806. DOI: 10.3390/ijms25179186.

Effects of in utero exposure to Δ-9-tetrahydrocannabinol on cardiac extracellular matrix expression and vascular transcriptome in rhesus macaques.

Le H, Shorey-Kendrick L, Hinds M, McCarty O, Lo J, Anderson D Am J Physiol Heart Circ Physiol. 2024; 327(3):H701-H714.

PMID: 39028280 PMC: 11442028. DOI: 10.1152/ajpheart.00181.2024.

Engineering cell-derived extracellular matrix for peripheral nerve regeneration.

Xu Y, Liu X, Ahmad M, Ao Q, Yu Y, Shao D Mater Today Bio. 2024; 27:101125.

PMID: 38979129 PMC: 11228803. DOI: 10.1016/j.mtbio.2024.101125.

Chronic Cardiotoxicity Assays Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs).

Narkar A, Willard J, Blinova K Int J Mol Sci. 2022; 23(6).

PMID: 35328619 PMC: 8953833. DOI: 10.3390/ijms23063199.

References

Richards E, Wood C, Rabaglino M, Antolic A, Keller-Wood M . Mechanisms for the adverse effects of late gestational increases in maternal cortisol on the heart revealed by transcriptomic analyses of the fetal septum. Physiol Genomics. 2014; 46(15):547-59. PMC: 4121623. DOI: 10.1152/physiolgenomics.00009.2014. View

Eberle C, Kirchner M, Herden R, Stichling S . Paternal metabolic and cardiovascular programming of their offspring: A systematic scoping review. PLoS One. 2020; 15(12):e0244826. PMC: 7775047. DOI: 10.1371/journal.pone.0244826. View

Fonoudi H, Bosman A . Turning Potential Into Action: Using Pluripotent Stem Cells to Understand Heart Development and Function in Health and Disease. Stem Cells Transl Med. 2017; 6(6):1452-1457. PMC: 5689742. DOI: 10.1002/sctm.16-0476. View

Roseboom T . Epidemiological evidence for the developmental origins of health and disease: effects of prenatal undernutrition in humans. J Endocrinol. 2019; 242(1):T135-T144. DOI: 10.1530/JOE-18-0683. View

Snider A, Wood J . Obesity induces ovarian inflammation and reduces oocyte quality. Reproduction. 2019; 158(3):R79-R90. DOI: 10.1530/REP-18-0583. View

Wu J, Izpisua Belmonte J . Stem Cells: A Renaissance in Human Biology Research. Cell. 2016; 165(7):1572-1585. DOI: 10.1016/j.cell.2016.05.043. View

Crean A, Bonduriansky R . What is a paternal effect?. Trends Ecol Evol. 2014; 29(10):554-9. DOI: 10.1016/j.tree.2014.07.009. View

Siddeek B, Mauduit C, Chehade H, Blin G, Liand M, Chindamo M . Long-term impact of maternal high-fat diet on offspring cardiac health: role of micro-RNA biogenesis. Cell Death Discov. 2019; 5:71. PMC: 6397280. DOI: 10.1038/s41420-019-0153-y. View

van Weerd J, Koshiba-Takeuchi K, Kwon C, Takeuchi J . Epigenetic factors and cardiac development. Cardiovasc Res. 2011; 91(2):203-11. PMC: 3125076. DOI: 10.1093/cvr/cvr138. View

10.

Schindler Y, Garske K, Wang J, Firulli B, Firulli A, Poss K . Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration. Development. 2014; 141(16):3112-22. PMC: 4197543. DOI: 10.1242/dev.106336. View

11.

Torrens C, Snelling T, Chau R, Shanmuganathan M, Cleal J, Poore K . Effects of pre- and periconceptional undernutrition on arterial function in adult female sheep are vascular bed dependent. Exp Physiol. 2009; 94(9):1024-33. DOI: 10.1113/expphysiol.2009.047340. View

12.

Sharma A, Sances S, Workman M, Svendsen C . Multi-lineage Human iPSC-Derived Platforms for Disease Modeling and Drug Discovery. Cell Stem Cell. 2020; 26(3):309-329. PMC: 7159985. DOI: 10.1016/j.stem.2020.02.011. View

13.

Long F, Wang Q, Yang D, Zhu M, Wang J, Zhu Y . Targeting JMJD3 histone demethylase mediates cardiac fibrosis and cardiac function following myocardial infarction. Biochem Biophys Res Commun. 2020; 528(4):671-677. DOI: 10.1016/j.bbrc.2020.05.115. View

14.

Wang Q, Song J, Liu Y, Zhao X . Involvement of Wnt pathway in ethanol-induced inhibition of mouse embryonic stem cell differentiation. Alcohol. 2017; 58:13-18. DOI: 10.1016/j.alcohol.2016.11.006. View

15.

Zhang Q, Tran T, Wang M, Ranek M, Kokkonen-Simon K, Gao J . Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis. Nat Commun. 2018; 9(1):5230. PMC: 6286331. DOI: 10.1038/s41467-018-07173-2. View

16.

Liu Y, Steinbusch L, Nabben M, Kapsokalyvas D, van Zandvoort M, Schonleitner P . Palmitate-Induced Vacuolar-Type H-ATPase Inhibition Feeds Forward Into Insulin Resistance and Contractile Dysfunction. Diabetes. 2017; 66(6):1521-1534. DOI: 10.2337/db16-0727. View

17.

Piquereau J, Ventura-Clapier R . Maturation of Cardiac Energy Metabolism During Perinatal Development. Front Physiol. 2018; 9:959. PMC: 6060230. DOI: 10.3389/fphys.2018.00959. View

18.

Sun C, Burgner D, Ponsonby A, Saffery R, Huang R, Vuillermin P . Effects of early-life environment and epigenetics on cardiovascular disease risk in children: highlighting the role of twin studies. Pediatr Res. 2013; 73(4 Pt 2):523-30. DOI: 10.1038/pr.2013.6. View

19.

Zhu Z, Cao F, Li X . Epigenetic Programming and Fetal Metabolic Programming. Front Endocrinol (Lausanne). 2019; 10:764. PMC: 6901800. DOI: 10.3389/fendo.2019.00764. View

20.

Jha R, Xu R, Xu C . Efficient differentiation of cardiomyocytes from human pluripotent stem cells with growth factors. Methods Mol Biol. 2015; 1299:115-31. PMC: 4886660. DOI: 10.1007/978-1-4939-2572-8_9. View