Antibiotic Resistance: From Pig to Meat

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2021 Oct 23

PMID 34680790

Citations 33

Authors

Xavier C Monger

Alex-An Gilbert

Linda Saucier

Antony T Vincent

Affiliations

Soon will be listed here.

Abstract

Pork meat is in high demand worldwide and this is expected to increase. Pork is often raised in intensive conditions, which is conducive to the spread of infectious diseases. Vaccines, antibiotics, and other biosafety measures help mitigate the impact of infectious diseases. However, bacterial strains resistant to antibiotics are more and more frequently found in pig farms, animals, and the environment. It is now recognized that a holistic perspective is needed to sustainably fight antibiotic resistance, and that an integrated One Health approach is essential. With this in mind, this review tackles antibiotic resistance throughout the pork raising process, including their microbiome; many factors of their environment (agricultural workers, farms, rivers, etc.); and an overview of the impact of antibiotic resistance on pork meat, which is the end product available to consumers. Antibiotic resistance, while a natural process, is a public health concern. If we react, and act, collectively, it is expected to be, at least partially, reversible with judicious antibiotic usage and the development of innovative strategies and tools to foster animal health.

Citing Articles

Modeled sustainability impacts of increasing pork consumption among adults in the United States.

Conrad Z, Repoulis V, Zavela C Front Nutr. 2025; 11:1508601.

PMID: 39897535 PMC: 11783847. DOI: 10.3389/fnut.2024.1508601.

Antibiotic Residues in Animal Products from Some African Countries and Their Possible Impact on Human Health.

Oladeji O, Mugivhisa L, Olowoyo J Antibiotics (Basel). 2025; 14(1).

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In vitro characterization of lactic acid bacteria and bifidobacteria from wild and domestic pigs: probiotic potential for post-weaning piglets.

Kavanova K, Kostovova I, Moravkova M, Kubasova T, Crhanova M BMC Microbiol. 2025; 25(1):8.

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Combined effect of Tetracycline compounds and essential oils on antimicrobial resistant isolated from the swine food chain.

Maggio F, Lauteri C, Rossi C, Ferri G, Serio A, Vergara A Front Microbiol. 2025; 15:1439286.

PMID: 39741589 PMC: 11687403. DOI: 10.3389/fmicb.2024.1439286.

Resilience of Loin Meat Microbiota and of Resistance Genes to a Chlortetracycline Treatment in Weaned Piglets.

Monger X, Saucier L, Gilbert A, Gosselin S, Pouliot E, Fournaise S Antibiotics (Basel). 2024; 13(10).

PMID: 39452263 PMC: 11504350. DOI: 10.3390/antibiotics13100997.

References

Pi Y, Gao K, Peng Y, Mu C, Zhu W . Antibiotic-induced alterations of the gut microbiota and microbial fermentation in protein parallel the changes in host nitrogen metabolism of growing pigs. Animal. 2018; 13(2):262-272. DOI: 10.1017/S1751731118001416. View

Gao Q, Gao S, Bates C, Zeng Y, Lei J, Su H . The microbial network property as a bio-indicator of antibiotic transmission in the environment. Sci Total Environ. 2020; 758:143712. DOI: 10.1016/j.scitotenv.2020.143712. View

Jacobson A, Lam L, Rajendram M, Tamburini F, Honeycutt J, Pham T . A Gut Commensal-Produced Metabolite Mediates Colonization Resistance to Salmonella Infection. Cell Host Microbe. 2018; 24(2):296-307.e7. PMC: 6223613. DOI: 10.1016/j.chom.2018.07.002. View

Sun J, Liao X, DSouza A, Boolchandani M, Li S, Cheng K . Environmental remodeling of human gut microbiota and antibiotic resistome in livestock farms. Nat Commun. 2020; 11(1):1427. PMC: 7080799. DOI: 10.1038/s41467-020-15222-y. View

Argudin M, Deplano A, Meghraoui A, Dodemont M, Heinrichs A, Denis O . Bacteria from Animals as a Pool of Antimicrobial Resistance Genes. Antibiotics (Basel). 2017; 6(2). PMC: 5485445. DOI: 10.3390/antibiotics6020012. View

Mbareche H, Veillette M, Pilote J, Letourneau V, Duchaine C . Bioaerosols Play a Major Role in the Nasopharyngeal Microbiota Content in Agricultural Environment. Int J Environ Res Public Health. 2019; 16(8). PMC: 6518280. DOI: 10.3390/ijerph16081375. View

Saucier L . Microbial spoilage, quality and safety within the context of meat sustainability. Meat Sci. 2016; 120:78-84. DOI: 10.1016/j.meatsci.2016.04.027. View

Che L, Hu Q, Wang R, Zhang D, Liu C, Zhang Y . Inter-correlated gut microbiota and SCFAs changes upon antibiotics exposure links with rapid body-mass gain in weaned piglet model. J Nutr Biochem. 2019; 74:108246. DOI: 10.1016/j.jnutbio.2019.108246. View

Holmer I, Salomonsen C, Jorsal S, Astrup L, Jensen V, Hog B . Antibiotic resistance in porcine pathogenic bacteria and relation to antibiotic usage. BMC Vet Res. 2019; 15(1):449. PMC: 6907208. DOI: 10.1186/s12917-019-2162-8. View

10.

Stanton T, Humphrey S, Stoffregen W . Chlortetracycline-resistant intestinal bacteria in organically raised and feral Swine. Appl Environ Microbiol. 2011; 77(20):7167-70. PMC: 3194871. DOI: 10.1128/AEM.00688-11. View

11.

Teng C, Wu P, Tang S, Chen Y, Cheng M, Huang P . A Large Spatial Survey of Colistin-Resistant Gene -Carrying in Rivers across Taiwan. Microorganisms. 2021; 9(4). PMC: 8066897. DOI: 10.3390/microorganisms9040722. View

12.

Dhabhar F, McEwen B . Acute stress enhances while chronic stress suppresses cell-mediated immunity in vivo: a potential role for leukocyte trafficking. Brain Behav Immun. 1998; 11(4):286-306. DOI: 10.1006/brbi.1997.0508. View

13.

Osterberg J, Wingstrand A, Jensen A, Kerouanton A, Cibin V, Barco L . Antibiotic Resistance in Escherichia coli from Pigs in Organic and Conventional Farming in Four European Countries. PLoS One. 2016; 11(6):e0157049. PMC: 4928804. DOI: 10.1371/journal.pone.0157049. View

14.

Yan H, Zhang L, Guo Z, Zhang H, Liu J . Production Phase Affects the Bioaerosol MicrobialComposition and Functional Potential in SwineConfinement Buildings. Animals (Basel). 2019; 9(3). PMC: 6466638. DOI: 10.3390/ani9030090. View

15.

Gibbs S, Green C, Tarwater P, Mota L, Mena K, Scarpino P . Isolation of antibiotic-resistant bacteria from the air plume downwind of a swine confined or concentrated animal feeding operation. Environ Health Perspect. 2006; 114(7):1032-7. PMC: 1513331. DOI: 10.1289/ehp.8910. View

16.

Muurinen J, Richert J, Wickware C, Richert B, Johnson T . Swine growth promotion with antibiotics or alternatives can increase antibiotic resistance gene mobility potential. Sci Rep. 2021; 11(1):5485. PMC: 7970892. DOI: 10.1038/s41598-021-84759-9. View

17.

Guerrero-Ramos E, Cordero J, Molina-Gonzalez D, Poeta P, Igrejas G, Alonso-Calleja C . Antimicrobial resistance and virulence genes in enterococci from wild game meat in Spain. Food Microbiol. 2015; 53(Pt B):156-64. DOI: 10.1016/j.fm.2015.09.007. View

18.

Desiree K, Mosimann S, Ebner P . Efficacy of phage therapy in pigs: systematic review and meta-analysis. J Anim Sci. 2021; 99(7). PMC: 8280926. DOI: 10.1093/jas/skab157. View

19.

Bower C, Daeschel M . Resistance responses of microorganisms in food environments. Int J Food Microbiol. 1999; 50(1-2):33-44. DOI: 10.1016/s0168-1605(99)00075-6. View

20.

Dowarah R, Verma A, Agarwal N, Singh P, Singh B . Selection and characterization of probiotic lactic acid bacteria and its impact on growth, nutrient digestibility, health and antioxidant status in weaned piglets. PLoS One. 2018; 13(3):e0192978. PMC: 5843174. DOI: 10.1371/journal.pone.0192978. View