Hypervalent Iodine-Mediated Late-Stage Peptide and Protein Functionalization

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2021 Oct 21

PMID 34674359

Citations 12

Authors

Emmanuelle M D Allouche

Elija Grinhagena

Jerome Waser

Affiliations

Soon will be listed here.

Abstract

Hypervalent iodine compounds are powerful reagents for the development of novel transformations. As they exhibit low toxicity, high functional group tolerance, and stability in biocompatible media, they have been used for the functionalization of biomolecules. Herein, we report recent advances up to June 2021 in peptide and protein modification using hypervalent iodine reagents. Their use as group transfer or oxidizing reagents is discussed in this Minireview, including methods targeting polar, aromatic, or aliphatic amino acids and peptide termini.

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