Tumor Microenvironment Modulating Functional Nanoparticles for Effective Cancer Treatments

Overview

Journal Tissue Eng Regen Med

Date 2021 Oct 21

PMID 34674182

Citations 9

Authors

Seungyong Shin

Jiyoung Lee

Jieun Han

Fangyuan Li

Daishun Ling

Wooram Park

Affiliations

Soon will be listed here.

Abstract

Cancer is one of the major diseases that threaten human life worldwide. Despite advances in cancer treatment techniques, such as radiation therapy, chemotherapy, targeted therapy, and immunotherapy, it is still difficult to cure cancer because of the resistance mechanism of cancer cells. Current understanding of tumor biology has revealed that resistance to these anticancer therapies is due to the tumor microenvironment (TME) represented by hypoxia, acidity, dense extracellular matrix, and immunosuppression. This review demonstrates the latest strategies for effective cancer treatment using functional nanoparticles that can modulate the TME. Indeed, preclinical studies have shown that functional nanoparticles can effectively modulate the TME to treat refractory cancer. This strategy of using TMEs with controllable functional nanoparticles is expected to maximize cancer treatment efficiency in the future by combining it with various modern cancer therapeutics.

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