Contributions of NFKB1 -94insertion/deletion ATTG Polymorphism to the Susceptibility of Gastrointestinal Cancers: A Meta-analysis

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2021 Oct 21

PMID 34672421

Citations 2

Authors

Hanqiang Wu

Jianrong Liang

Affiliations

Soon will be listed here.

Abstract

Nuclear factor-kappa B1 (NF-κB1), a pleiotropic transcription factor, functions as a critical contributor to tumorigenesis. Growing numbers of case-control studies were carried out to analyse the potential contribution of NF-κB1 gene variants to gastrointestinal cancer risk, yet remains conflicting conclusions. Therefore, we conducted this most up-to-date meta-analysis to evaluate the relationship between NF-κB1 gene insertion (I)/deletion (D) polymorphism, namely -94ins/delATTG or rs28362491, and the susceptibility to gastrointestinal cancers. We searched PubMed, EMBASE and MEDLINE databases updated in April 2021 for relevant studies. Meta-analysis was carried out by software Stata11.0. The quantification of the relationship was determined by computing the combined odds ratios (ORs) and their corresponding 95% confidence intervals (CIs). Sensitivity analysis, the funnel plot and Begg's rank correlation test were also applied. Our findings indicate that -94ins/delATTG polymorphism could not significantly impact the susceptibility to gastrointestinal cancers. Under any five genetic models, -94ins/delATTG polymorphism was not remarkedly linked to the risk of colorectal, gastric and oesophageal cancer, respectively. The significant role of -94ins/delATTG was only observed in some certain subgroups. Findings here suggest that NF-κB1 gene -94ins/delATTG polymorphism may not predispose to gastrointestinal cancer susceptibility.

Citing Articles

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PMID: 38273295 PMC: 10809652. DOI: 10.1186/s12964-023-01421-9.

Contributions of NFKB1 -94insertion/deletion ATTG polymorphism to the susceptibility of gastrointestinal cancers: A meta-analysis.

Wu H, Liang J J Cell Mol Med. 2021; 25(22):10674-10683.

PMID: 34672421 PMC: 8581328. DOI: 10.1111/jcmm.17004.

References

Luo J, Li Y, Fang B, Tian T, Liu F, Li X . NFKB1 gene rs28362491 ins/del variation is associated with higher susceptibility to myocardial infarction in a Chinese Han population. Sci Rep. 2020; 10(1):19518. PMC: 7658993. DOI: 10.1038/s41598-020-72877-9. View

Wa Q, Huang S, Pan J, Tang Y, He S, Fu X . miR-204-5p Represses Bone Metastasis via Inactivating NF-κB Signaling in Prostate Cancer. Mol Ther Nucleic Acids. 2019; 18:567-579. PMC: 6838892. DOI: 10.1016/j.omtn.2019.09.008. View

Yi W, Wen Y, Tan F, Liu X, Lan H, Ye H . Impact of NF-κB pathway on the apoptosis-inflammation-autophagy crosstalk in human degenerative nucleus pulposus cells. Aging (Albany NY). 2019; 11(17):7294-7306. PMC: 6756901. DOI: 10.18632/aging.102266. View

Arisawa T, Tahara T, Shiroeda H, Yamada K, Nomura T, Yamada H . Functional promoter polymorphisms of NFKB1 influence susceptibility to the diffuse type of gastric cancer. Oncol Rep. 2013; 30(6):3013-9. DOI: 10.3892/or.2013.2768. View

Ungerback J, Belenki D, Jawad ul-Hassan A, Fredrikson M, Fransen K, Elander N . Genetic variation and alterations of genes involved in NFκB/TNFAIP3- and NLRP3-inflammasome signaling affect susceptibility and outcome of colorectal cancer. Carcinogenesis. 2012; 33(11):2126-34. DOI: 10.1093/carcin/bgs256. View

Wang X, Hayes J, Xu X, Gao X, Mehta D, Lilja H . Validation of prostate cancer risk variants rs10993994 and rs7098889 by CRISPR/Cas9 mediated genome editing. Gene. 2020; 768:145265. PMC: 7796996. DOI: 10.1016/j.gene.2020.145265. View

Cao M, Li H, Sun D, Chen W . Cancer burden of major cancers in China: A need for sustainable actions. Cancer Commun (Lond). 2020; 40(5):205-210. PMC: 7667573. DOI: 10.1002/cac2.12025. View

Sen R, Baltimore D . Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 1986. 46: 705-716. J Immunol. 2006; 177(11):7485-96. View

Shen H, Liao B, Wan Z, Zhao Y, You Z, Liu J . PTOV1 promotes cisplatin-induced chemotherapy resistance by activating the nuclear factor kappa B pathway in ovarian cancer. Mol Ther Oncolytics. 2021; 20:499-507. PMC: 7937561. DOI: 10.1016/j.omto.2021.02.008. View

10.

Jiang Y, Wan Y, Gong M, Zhou S, Qiu J, Cheng W . RNA demethylase ALKBH5 promotes ovarian carcinogenesis in a simulated tumour microenvironment through stimulating NF-κB pathway. J Cell Mol Med. 2020; 24(11):6137-6148. PMC: 7294121. DOI: 10.1111/jcmm.15228. View

11.

Fu W, Zhuo Z, Chen Y, Zhu J, Zhao Z, Jia W . NFKB1 -94insertion/deletion ATTG polymorphism and cancer risk: Evidence from 50 case-control studies. Oncotarget. 2017; 8(6):9806-9822. PMC: 5354772. DOI: 10.18632/oncotarget.14190. View

12.

Hayden M, Ghosh S . Shared principles in NF-kappaB signaling. Cell. 2008; 132(3):344-62. DOI: 10.1016/j.cell.2008.01.020. View

13.

Hamadou I, Garritano S, Romanel A, Naimi D, Hammada T, Demichelis F . Inherited variant in NFκB-1 promoter is associated with increased risk of IBD in an Algerian population and modulates SOX9 binding. Cancer Rep (Hoboken). 2020; 3(3):e1240. PMC: 7941421. DOI: 10.1002/cnr2.1240. View

14.

Jiang T, Wang F, Wang Y, Hu J, Ding P, Lin J . Germline mutational profile of Chinese patients under 70 years old with colorectal cancer. Cancer Commun (Lond). 2020; 40(11):620-632. PMC: 7668457. DOI: 10.1002/cac2.12093. View

15.

Song S, Chen D, Lu J, Liao J, Luo Y, Yang Z . NFκB1 and NFκBIA polymorphisms are associated with increased risk for sporadic colorectal cancer in a southern Chinese population. PLoS One. 2011; 6(6):e21726. PMC: 3128094. DOI: 10.1371/journal.pone.0021726. View

16.

Riemann K, Becker L, Struwe H, Nuckel H, Duhrsen U, Alakus H . No association of the NFKB1 insertion/deletion promoter polymorphism with survival in colorectal and renal cell carcinoma as well as disease progression in B-cell chronic lymphocytic leukemia. Pharmacogenet Genomics. 2006; 16(11):783-8. DOI: 10.1097/01.fpc.0000230414.74726.f6. View

17.

Liu T, Han Y, Yu C, Ji Y, Wang C, Chen X . MYC predetermines the sensitivity of gastrointestinal cancer to antifolate drugs through regulating TYMS transcription. EBioMedicine. 2019; 48:289-300. PMC: 6838448. DOI: 10.1016/j.ebiom.2019.10.003. View

18.

Andersen V, Christensen J, Overvad K, Tjonneland A, Vogel U . Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes. BMC Cancer. 2010; 10:484. PMC: 2949803. DOI: 10.1186/1471-2407-10-484. View

19.

Kopp T, Andersen V, Tjonneland A, Vogel U . Polymorphisms in NFKB1 and TLR4 and interaction with dietary and life style factors in relation to colorectal cancer in a Danish prospective case-cohort study. PLoS One. 2015; 10(2):e0116394. PMC: 4337910. DOI: 10.1371/journal.pone.0116394. View

20.

von Mehren M, Joensuu H . Gastrointestinal Stromal Tumors. J Clin Oncol. 2017; 36(2):136-143. PMC: 6553810. DOI: 10.1200/JCO.2017.74.9705. View