An On-surface Diels-Alder Reaction

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2021 Oct 19

PMID 34664770

Citations 3

Authors

Jesus Castro-Esteban

Florian Albrecht

Shadi Fatayer

Dolores Perez

Leo Gross

Diego Pena

Affiliations

Soon will be listed here.

Abstract

The Diels-Alder reaction is one of the most popular reactions in organic chemistry. However, its use in the field of on-surface synthesis is hampered by the spatial restrictions of this cycloaddition reaction. Herein we selected a cyclic strained triyne to demonstrate an on-surface hexadehydro-Diels-Alder reaction in a single molecule. The reaction was studied in detail by means of atomic force microscopy (AFM) with CO-functionalized tips. Our results pave the way to use this iconic pericyclic reaction for on-surface synthesis, introducing the concept of atom economy in the field.

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An on-surface Diels-Alder reaction.

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PMID: 34664770 PMC: 9298865. DOI: 10.1002/anie.202110311.

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