Clinical Molecular and Genomic Epidemiology of in China

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2021 Oct 15

PMID 34650543

Citations 12

Authors

Guoxiu Xiang

Kai Lan

Yimei Cai

Kang Liao

Mei Zhao

Jia Tao

Yi Ma

Jianming Zeng

Weizheng Zhang

Zhongwen Wu

Xuegao Yu

Yuyang Liu

Yang Lu

Caixia Xu

Liang Chen

Yi-Wei Tang

Cha Chen

Wei Jia

Bin Huang

Affiliations

Soon will be listed here.

Abstract

Ongoing acquisition of antimicrobial resistance genes has made a new clinical treatment challenge. Understanding the molecular epidemiology of will contribute to clinical treatment and prevention. We undertook a 6-year clinical molecular epidemiological investigation of from three tertiary hospitals in China since 2014. Antimicrobial susceptibility testing was performed using a VITEK-2 system. All isolates were screened for β-lactam and plasmid-mediated quinolone resistance genes by PCR. Isolates carrying carbapenem-resistant genes were subjected to whole-genome sequencing (WGS). The variation and evolution of these mobile genetic elements (MGEs) were then systematically analyzed. Among all isolates ( = 335), forty (11.9%) were recognized as multidrug resistant strains. , , , and were the top four most prevalent resistance genes. Notably, phylogenomic and population structure analysis suggested clade 1 (rhierBAPS SC3 and SC5) associated with multiple resistance genes seemed to be widely spread. WGS showed a -carrying IncX3 plasmid and a genomic island 2 variant carrying , coexisted in the same multidrug resistant strain zy_m28. Additionally, a -carrying IncP-1β type plasmid was found in the strain nx_m63. This study indicates a clade of is prone to acquire resistance genes, and multidrug resistant are increasing by harboring a variety of MGEs including two newly discovered ones in the species. We should be vigilant that may bring more extensive and challenging antimicrobial resistance issue.

Citing Articles

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Genomic epidemiology and antimicrobial resistance of clinical isolates between 2016 and 2023.

Zhu W, Liu Q, Liu J, Wang Y, Shen H, Wei M Front Cell Infect Microbiol. 2025; 14:1464736.

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An insight into the genome-wide analysis of bacterial defense mechanisms in a uropathogenic Morganella morganii isolate from Bangladesh.

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Characteristics of gut microbiome in patients with pediatric solid tumor.

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