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Reactive Oxygen Species in Chronic Obstructive Pulmonary Disease

Overview
Journal Oxid Med Cell Longev
Publisher Wiley
Specialties Cell Biology
Endocrinology
Date 2018 Mar 31
PMID 29599897
Citations 100
Authors
Samia Boukhenouna
Mark A Wilson
Karim Bahmed
Beata Kosmider
Affiliations
Soon will be listed here.
Abstract

Chronic obstructive pulmonary disease (COPD) includes chronic bronchitis and emphysema. Environmental exposure, primarily cigarette smoking, can cause high oxidative stress and is the main factor of COPD development. Cigarette smoke also contributes to the imbalance of oxidant/antioxidant due to exogenous reactive oxygen species (ROS). Moreover, endogenously released ROS during the inflammatory process and mitochondrial dysfunction may contribute to this disease progression. ROS and reactive nitrogen species (RNS) can oxidize different biomolecules such as DNA, proteins, and lipids leading to epithelial cell injury and death. Various detoxifying enzymes and antioxidant defense systems can be involved in ROS removal. In this review, we summarize the main findings regarding the biological role of ROS, which may contribute to COPD development, and cytoprotective mechanisms against this disease progression.

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