Recent Advances in Sensitivity Enhancement for Lateral Flow Assay

Overview

Journal Mikrochim Acta

Specialties Biotechnology
Chemistry

Date 2021 Oct 14

PMID 34647157

Citations 20

Authors

Yulin Deng

Hao Jiang

Xiaoqiong Li

Xuefei Lv

Affiliations

Soon will be listed here.

Abstract

Conventional lateral flow assay (LFA) is typically performed by observing the color changes in the test lines by naked eyes, which achieves considerable commercial success and has a significant impact on the fields of food safety, environment monitoring, disease diagnosis, and other applications. However, this qualitative detection method is not very suitable for low levels of disease biomarkers' detection. Although many nanomaterials are used as new labels for LFA, additional readers limit their application to some extent. Fortunately, a lot of work has been done for improving the sensitivity of LFA. In this review, currently reported LFA sensitivity enhancement methods with an objective evaluation are summarized, such as sample pretreatment, the change of flow rate, and label evolution, and future development direction and challenges of LFAs are discussed.

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