Advancements in Nanobiosensor Technologies for In-vitro Diagnostics to Point of Care Testing

Overview

Journal Heliyon

Specialty Social Sciences

Date 2024 Dec 3

PMID 39624329

Authors

Chuntae Kim

Moon Sung Kang

Iruthayapandi Selestin Raja

Yoon Ki Joung

Dong-Wook Han

Affiliations

Soon will be listed here.

Abstract

Recently, the importance of rapid testing nanosensor technologies for in-vitro diagnostics (IVD) and point-of-care testing (POCT) is being increasingly recognized. Owing to their high sensitivity and rapidity, nanosensor-based diagnostic devices are evolving into self-diagnostic tools that enable real-time in-situ analyses. These advances have become the focus of the public health control system, not only to prevent the spread of infectious diseases but also to enable the early detection of critical diseases through continuous health monitoring technologies. Current research on rapid diagnostic nanosensor technologies has focused on improving accuracy, sensitivity, rapid test systems, cost-effectiveness, and accessibility. In this review, we discuss the development of self-testing IVD technologies based on rapid diagnostic nanosensor platforms. The convergence of nanosensors and advanced materials can provide faster, more accurate, and more accessible IVD-based POCT solutions, representing an important advancement in healthcare. Here, we present nanosensor technologies for diagnosing biomarkers in in-vitro samples and improving diagnostic efficiency. Nanosensor-based self-diagnostic devices have the potential to be extended to personalized healthcare platforms, enabling the continuous monitoring of infectious diseases, cancer, and other serious issues. This review highlights the importance of research in this field to improve diagnostic efficiency.

References

Moonga L, Hayashida K, Kawai N, Nakao R, Sugimoto C, Namangala B . Development of a Multiplex Loop-Mediated Isothermal Amplification (LAMP) Method for Simultaneous Detection of Spotted Fever Group Rickettsiae and Malaria Parasites by Dipstick DNA Chromatography. Diagnostics (Basel). 2020; 10(11). PMC: 7694008. DOI: 10.3390/diagnostics10110897. View

Mistry D, Wang J, Moeser M, Starkey T, Lee L . A systematic review of the sensitivity and specificity of lateral flow devices in the detection of SARS-CoV-2. BMC Infect Dis. 2021; 21(1):828. PMC: 8371300. DOI: 10.1186/s12879-021-06528-3. View

Holzinger M, Le Goff A, Cosnier S . Nanomaterials for biosensing applications: a review. Front Chem. 2014; 2:63. PMC: 4145256. DOI: 10.3389/fchem.2014.00063. View

Chehelgerdi M, Chehelgerdi M, Allela O, Pecho R, Jayasankar N, Rao D . Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation. Mol Cancer. 2023; 22(1):169. PMC: 10561438. DOI: 10.1186/s12943-023-01865-0. View

Qin J, Wang W, Gao L, Yao S . Emerging biosensing and transducing techniques for potential applications in point-of-care diagnostics. Chem Sci. 2022; 13(10):2857-2876. PMC: 8905799. DOI: 10.1039/d1sc06269g. View

Lingervelder D, Koffijberg H, Kusters R, IJzerman M . Health Economic Evidence of Point-of-Care Testing: A Systematic Review. Pharmacoecon Open. 2021; 5(2):157-173. PMC: 8160040. DOI: 10.1007/s41669-020-00248-1. View

Kadam U, Cho Y, Park T, Hong J . Aptamer-based CRISPR-Cas powered diagnostics of diverse biomarkers and small molecule targets. Appl Biol Chem. 2023; 66(1):13. PMC: 9937869. DOI: 10.1186/s13765-023-00771-9. View

Everitt M, Tillery A, David M, Singh N, Borison A, White I . A critical review of point-of-care diagnostic technologies to combat viral pandemics. Anal Chim Acta. 2021; 1146:184-199. PMC: 7548029. DOI: 10.1016/j.aca.2020.10.009. View

Barnes K, Lachenauer A, Nitido A, Siddiqui S, Gross R, Beitzel B . Deployable CRISPR-Cas13a diagnostic tools to detect and report Ebola and Lassa virus cases in real-time. Nat Commun. 2020; 11(1):4131. PMC: 7431545. DOI: 10.1038/s41467-020-17994-9. View

10.

Kamali H, Golmohammadzadeh S, Zare H, Nosrati R, Fereidouni M, Safarpour H . The recent advancements in the early detection of cancer biomarkers by DNAzyme-assisted aptasensors. J Nanobiotechnology. 2022; 20(1):438. PMC: 9531510. DOI: 10.1186/s12951-022-01640-1. View

11.

Fu X, Cheng Z, Yu J, Choo P, Chen L, Choo J . A SERS-based lateral flow assay biosensor for highly sensitive detection of HIV-1 DNA. Biosens Bioelectron. 2015; 78:530-537. DOI: 10.1016/j.bios.2015.11.099. View

12.

Miller L, Simmons M, Silver C, Krauss T, Thomas G, Johnson S . Antibiotic-functionalized gold nanoparticles for the detection of active β-lactamases. Nanoscale Adv. 2022; 4(2):573-581. PMC: 9419081. DOI: 10.1039/d1na00635e. View

13.

Kim C, Lee H, Devaraj V, Kim W, Lee Y, Kim Y . Hierarchical Cluster Analysis of Medical Chemicals Detected by a Bacteriophage-Based Colorimetric Sensor Array. Nanomaterials (Basel). 2020; 10(1). PMC: 7023180. DOI: 10.3390/nano10010121. View

14.

Wang B, Peng T, Jiang Z, Xu J, Qu J, Dai X . Highly Sensitive and Quantitative Magnetic Nanoparticle-Based Lateral Flow Immunoassay with an Atomic Magnetometer. ACS Sens. 2023; 8(12):4512-4520. DOI: 10.1021/acssensors.3c01028. View

15.

Shaw J . Point-of-Care Testing: The Good, the Bad, and the Laboratory Oversight. J Appl Lab Med. 2020; 6(4):1090-1093. DOI: 10.1093/jalm/jfaa200. View

16.

Tang Z, Nouri R, Dong M, Yang J, Greene W, Zhu Y . Rapid detection of novel coronavirus SARS-CoV-2 by RT-LAMP coupled solid-state nanopores. Biosens Bioelectron. 2021; 197:113759. PMC: 8560184. DOI: 10.1016/j.bios.2021.113759. View

17.

Huang C, Wen T, Shi F, Zeng X, Jiao Y . Rapid Detection of IgM Antibodies against the SARS-CoV-2 Virus via Colloidal Gold Nanoparticle-Based Lateral-Flow Assay. ACS Omega. 2020; 5(21):12550-12556. PMC: 7241732. DOI: 10.1021/acsomega.0c01554. View

18.

Suwannin P, Polpanich D, Leelayoova S, Mungthin M, Tangboriboonrat P, Elaissari A . Heat-enhancing aggregation of gold nanoparticles combined with loop-mediated isothermal amplification (HAG-LAMP) for Plasmodium falciparum detection. J Pharm Biomed Anal. 2021; 203:114178. DOI: 10.1016/j.jpba.2021.114178. View

19.

Pardee K, Green A, Takahashi M, Braff D, Lambert G, Lee J . Rapid, Low-Cost Detection of Zika Virus Using Programmable Biomolecular Components. Cell. 2016; 165(5):1255-1266. DOI: 10.1016/j.cell.2016.04.059. View

20.

Savva K, Kawka M, Vadhwana B, Penumaka R, Patton I, Khan K . The Biomarker Toolkit - an evidence-based guideline to predict cancer biomarker success and guide development. BMC Med. 2023; 21(1):383. PMC: 10552368. DOI: 10.1186/s12916-023-03075-3. View