The Mucosal Immune System and IgA Nephropathy

Overview

Journal Semin Immunopathol

Publisher Springer

Specialties Allergy & Immunology
Pathology

Date 2021 Oct 13

PMID 34642783

Citations 52

Authors

Loreto Gesualdo

Vincenzo Di Leo

Rosanna Coppo

Affiliations

Soon will be listed here.

Abstract

The precise pathogenesis of immunoglobulin A nephropathy (IgAN) is still not clearly established but emerging evidence confirms a pivotal role for mucosal immunity. This review focuses on the key role of mucosa-associated lymphoid tissue (MALT) in promoting the onset of the disease, underlying the relationship among microbiota, genetic factors, food antigen, infections, and mucosal immune response. Finally, we evaluate potential therapies targeting microbes and mucosa hyperresponsiveness in IgAN patients.

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