A Combination of Methylation and Protein Markers is Capable of Detecting Gastric Cancer detection by Combined Markers

This study aimed to validate a combination of , and CA724 for gastric cancer (GC) detection. The performance of , and CA724 was examined in a prospective cohort study with 518 participants (151 with GC, 56 with atrophic gastritis, 87 with other gastrointestinal diseases and 224 with no evidence of disease). , or CA724 alone detected 48.3, 37.1 and 43.1% of GC, respectively. The combination of and detected 60.3% of GC, and the combination of all three markers detected 68.6% of GC. The detection sensitivity of and was significantly higher for gastric body and in elder subjects. was correlated with poorer GC survival. The combination of , and CA724 was adequately sensitive for GC detection. The blood was predictive for GC prognosis.