Diagnostic Value of Plasma RNF180 Gene Methylation for Gastric Cancer: A Systematic Review and Meta-analysis

Overview

Journal Front Oncol

Specialty Oncology

Date 2023 Jan 27

PMID 36703788

Authors

Tongxin Wang

Yating Zhang

Jianrong Wang

Yumin Li

Affiliations

Soon will be listed here.

Abstract

Objective: A systematic evaluation of the diagnostic value of Ring finger protein 180 (RNF180) gene methylation as a novel tumor marker for gastric cancer (GC) is required to improve the early diagnosis of gastric cancer patients.

Methods: Computer searches of PubMed, Web of Science, Embase, The Cochrane Library, CNKI, CBM, WanFang Data, National Research Register, Cclinical Controlled Trials, Opengrey and VIP databases were conducted from the database's inception to September 1, 2022. Two researchers independently screened the literature, extracted information, and assessed the risk of bias in studies that were included. The meta-analysis was carried out using RevMan 5.3 and Stata 16.0 software.

Results: A total of 9 studies with a total of 1531 subjects were included. A random-effects meta-analysis revealed that the combined sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) of plasma RNF180 gene methylation for the diagnosis of GC were: 0.54 [95% CI (0.45, 0.62)], 0.80 [95% CI (0.72, 0.87)], 2.73 [95% CI (2.09, 3.57)], 0.58 [95% CI (0.51, 0.65)], 4.74 [95% CI (3.59, 6.62)], respectively.

Conclusion: The detection of RNF180 gene methylation in plasma has a high diagnostic value for GC and is expected to be a potential biomarker for the diagnosis of gastric cancer, according to current evidence.

Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=370903, identifier CRD42022370903.

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References

Cao C, Chang L, Wu Q . Circulating methylated Septin 9 and ring finger protein 180 for noninvasive diagnosis of early gastric cancer. Transl Cancer Res. 2022; 9(11):7012-7021. PMC: 8799148. DOI: 10.21037/tcr-20-1330. View

Liu H, Yang P, Li X, Jia Y . Ring finger protein 180 is associated with biological behavior and prognosis in patients with non-small cell lung cancer. Oncol Lett. 2020; 20(4):35. PMC: 7412726. DOI: 10.3892/ol.2020.11898. View

Necula L, Matei L, Dragu D, Neagu A, Mambet C, Nedeianu S . Recent advances in gastric cancer early diagnosis. World J Gastroenterol. 2019; 25(17):2029-2044. PMC: 6506585. DOI: 10.3748/wjg.v25.i17.2029. View

Sun J, Zheng M, Li Y, Zhang S . Structure and function of Septin 9 and its role in human malignant tumors. World J Gastrointest Oncol. 2020; 12(6):619-631. PMC: 7340996. DOI: 10.4251/wjgo.v12.i6.619. View

Sung H, Ferlay J, Siegel R, Laversanne M, Soerjomataram I, Jemal A . Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021; 71(3):209-249. DOI: 10.3322/caac.21660. View

Han F, Sun L, Liu S, Xu Q, Liang Q, Zhang Z . Promoter methylation of RNF180 is associated with H.pylori infection and serves as a marker for gastric cancer and atrophic gastritis. Oncotarget. 2016; 7(17):24800-9. PMC: 5029743. DOI: 10.18632/oncotarget.8523. View

Avincsal M, Jimbo N, Fujikura K, Shinomiya H, Otsuki N, Morimoto K . Epigenetic down-regulation of SOX2 is an independent poor prognostic factor for hypopharyngeal cancers. Histopathology. 2017; 72(5):826-837. DOI: 10.1111/his.13436. View

Ogawa M, Mizugishi K, Ishiguro A, Koyabu Y, Imai Y, Takahashi R . Rines/RNF180, a novel RING finger gene-encoded product, is a membrane-bound ubiquitin ligase. Genes Cells. 2008; 13(4):397-409. DOI: 10.1111/j.1365-2443.2008.01169.x. View

Wu Z, Liu H, Sun W, Du Y, He W, Guo S . RNF180 mediates STAT3 activity by regulating the expression of RhoC via the proteasomal pathway in gastric cancer cells. Cell Death Dis. 2020; 11(10):881. PMC: 7575565. DOI: 10.1038/s41419-020-03096-3. View

10.

Shimada H, Noie T, Ohashi M, Oba K, Takahashi Y . Clinical significance of serum tumor markers for gastric cancer: a systematic review of literature by the Task Force of the Japanese Gastric Cancer Association. Gastric Cancer. 2013; 17(1):26-33. DOI: 10.1007/s10120-013-0259-5. View

11.

Gomez-Zamudio J, Mendoza-Zubieta V, Ferreira-Hermosillo A, Molina-Ayala M, Valladares-Salgado A, Suarez-Sanchez F . High Thyroid-stimulating Hormone Levels Increase Proinflammatory and Cardiovascular Markers in Patients with Extreme Obesity. Arch Med Res. 2016; 47(6):476-482. DOI: 10.1016/j.arcmed.2016.10.007. View

12.

Yang A, Liu J, Lei H, Zhang Q, Zhao L, Yang G . CA72-4 combined with CEA, CA125 and CAl9-9 improves the sensitivity for the early diagnosis of gastric cancer. Clin Chim Acta. 2014; 437:183-6. DOI: 10.1016/j.cca.2014.07.034. View

13.

Zhao Q, Guo T, Wang H, Zhang X, Zhang H, Wang Z . Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis. Onco Targets Ther. 2015; 8:3433-9. PMC: 4657794. DOI: 10.2147/OTT.S94300. View

14.

Wei F, Ba S, Jin M, Ci R, Wang X, E F . RNF180 Inhibits Proliferation and Promotes Apoptosis of Colorectal Cancer Through Ubiquitination of WISP1. Front Cell Dev Biol. 2021; 8:623455. PMC: 7862563. DOI: 10.3389/fcell.2020.623455. View

15.

Sun W, Ma G, Zhang L, Wang P, Zhang N, Wu Z . DNMT3A-mediated silence in ADAMTS9 expression is restored by RNF180 to inhibit viability and motility in gastric cancer cells. Cell Death Dis. 2021; 12(5):428. PMC: 8087691. DOI: 10.1038/s41419-021-03628-5. View

16.

Hanahan D, Weinberg R . Hallmarks of cancer: the next generation. Cell. 2011; 144(5):646-74. DOI: 10.1016/j.cell.2011.02.013. View

17.

Wang N, Sui F, Ma J, Su X, Liu J, Yao D . Site-specific Hypermethylation of RUNX3 Predicts Poor Prognosis in Gastric Cancer. Arch Med Res. 2016; 47(4):285-92. DOI: 10.1016/j.arcmed.2016.07.011. View

18.

Han F, Liu S, Jing J, Li H, Yuan Y, Sun L . Identification of High-Frequency Methylation Sites in RNF180 Promoter Region Affecting Expression and Their Relationship with Prognosis of Gastric Cancer. Cancer Manag Res. 2020; 12:3389-3399. PMC: 7231750. DOI: 10.2147/CMAR.S246995. View

19.

Deng J, Liang H, Ying G, Zhang R, Wang B, Yu J . Methylation of CpG sites in RNF180 DNA promoter prediction poor survival of gastric cancer. Oncotarget. 2014; 5(10):3173-83. PMC: 4102801. DOI: 10.18632/oncotarget.1888. View

20.

Deng J, Guo J, Guo X, Hou Y, Xie X, Sun C . Mediation of the malignant biological characteristics of gastric cancer cells by the methylated CpG islands in RNF180 DNA promoter. Oncotarget. 2016; 7(28):43461-43474. PMC: 5190037. DOI: 10.18632/oncotarget.9494. View