Recent Advances in Immunoassays and Biosensors for Mycotoxins Detection in Feedstuffs and Foods

Overview

Journal J Anim Sci Biotechnol

Publisher Biomed Central

Date 2021 Oct 11

PMID 34629116

Citations 16

Authors

Runxian Li

Yang Wen

Fenglai Wang

Pingli He

Affiliations

Soon will be listed here.

Abstract

Mycotoxins are secondary metabolites produced by fungus. Many mycotoxin species are highly toxic and are frequently found in cereals and feedstuffs. So, powerful detection methods are vital and effective ways to prevent feed contamination. Traditional detection methods can no longer meet the needs of massive, real-time, simple, and fast mycotoxin monitoring. Rapid detection methods based on advanced material and sensor technology are the future trend. In this review, we highlight recent progress of mycotoxin rapid detection strategies in feedstuffs and foods, especially for simultaneous multiplex mycotoxin determination. Immunoassays, biosensors, and the prominent roles of nanomaterials are introduced. The principles of different types of recognition and signal transduction are explained, and the merits and pitfalls of these methods are compared. Furthermore, limitations and challenges of existing rapid sensing strategies and perspectives of future research are discussed.

Citing Articles

Recent progress, challenges, and future perspectives of electrochemical biosensing of aflatoxins.

S D, Palakollu V, Vattikuti S, Shim J, Mameda N Mikrochim Acta. 2024; 192(1):17.

PMID: 39690256 DOI: 10.1007/s00604-024-06857-5.

Mycotoxin Biodegradation by Bacteria-A Review.

Nguyen T, Chen X, Ma L, Feng Y Toxins (Basel). 2024; 16(11).

PMID: 39591233 PMC: 11598562. DOI: 10.3390/toxins16110478.

mycotoxins: The major food contaminants.

Qu Z, Ren X, Du Z, Hou J, Li Y, Yao Y mLife. 2024; 3(2):176-206.

PMID: 38948146 PMC: 11211685. DOI: 10.1002/mlf2.12112.

Integrating Wireless Remote Sensing and Sensors for Monitoring Pesticide Pollution in Surface and Groundwater.

Mutunga T, Sinanovic S, Harrison C Sensors (Basel). 2024; 24(10).

PMID: 38794044 PMC: 11125874. DOI: 10.3390/s24103191.

Recent Advances in Electrochemiluminescence Biosensors for Mycotoxin Assay.

Jin L, Liu W, Xiao Z, Yang H, Yu H, Dong C Biosensors (Basel). 2023; 13(6).

PMID: 37367018 PMC: 10296450. DOI: 10.3390/bios13060653.

References

Alhamoud Y, Yang D, Fiati Kenston S, Liu G, Liu L, Zhou H . Advances in biosensors for the detection of ochratoxin A: Bio-receptors, nanomaterials, and their applications. Biosens Bioelectron. 2019; 141:111418. DOI: 10.1016/j.bios.2019.111418. View

Cao Y, Feng T, Xu J, Xue C . Recent advances of molecularly imprinted polymer-based sensors in the detection of food safety hazard factors. Biosens Bioelectron. 2019; 141:111447. DOI: 10.1016/j.bios.2019.111447. View

Khan I, Niazi S, Yu Y, Mohsin A, Mushtaq B, Iqbal M . Aptamer Induced Multicolored AuNCs-WS "Turn on" FRET Nano Platform for Dual-Color Simultaneous Detection of AflatoxinB and Zearalenone. Anal Chem. 2019; 91(21):14085-14092. DOI: 10.1021/acs.analchem.9b03880. View

Sun C, Liao X, Huang P, Shan G, Ma X, Fu L . A self-assembled electrochemical immunosensor for ultra-sensitive detection of ochratoxin A in medicinal and edible malt. Food Chem. 2020; 315:126289. DOI: 10.1016/j.foodchem.2020.126289. View

Shao Y, Duan H, Zhou S, Ma T, Guo L, Huang X . Biotin-Streptavidin System-Mediated Ratiometric Multiplex Immunochromatographic Assay for Simultaneous and Accurate Quantification of Three Mycotoxins. J Agric Food Chem. 2019; 67(32):9022-9031. DOI: 10.1021/acs.jafc.9b03222. View

Wang X, Park S, Ko J, Xiao X, Giannini V, Maier S . Sensitive and Reproducible Immunoassay of Multiple Mycotoxins Using Surface-Enhanced Raman Scattering Mapping on 3D Plasmonic Nanopillar Arrays. Small. 2018; 14(39):e1801623. DOI: 10.1002/smll.201801623. View

Gaudin V . Advances in biosensor development for the screening of antibiotic residues in food products of animal origin - A comprehensive review. Biosens Bioelectron. 2016; 90:363-377. DOI: 10.1016/j.bios.2016.12.005. View

Yang M, Cui M, Wang W, Yang Y, Chang J, Hao J . Background-free upconversion-encoded microspheres for mycotoxin detection based on a rapid visualization method. Anal Bioanal Chem. 2020; 412(1):81-91. DOI: 10.1007/s00216-019-02206-1. View

Wei T, Ren P, Huang L, Ouyang Z, Wang Z, Kong X . Simultaneous detection of aflatoxin B1, ochratoxin A, zearalenone and deoxynivalenol in corn and wheat using surface plasmon resonance. Food Chem. 2019; 300:125176. DOI: 10.1016/j.foodchem.2019.125176. View

10.

Gallo A, Giuberti G, Frisvad J, Bertuzzi T, Nielsen K . Review on Mycotoxin Issues in Ruminants: Occurrence in Forages, Effects of Mycotoxin Ingestion on Health Status and Animal Performance and Practical Strategies to Counteract Their Negative Effects. Toxins (Basel). 2015; 7(8):3057-111. PMC: 4549740. DOI: 10.3390/toxins7083057. View

11.

Wei M, Xin L, Feng S, Liu Y . Simultaneous electrochemical determination of ochratoxin A and fumonisin B1 with an aptasensor based on the use of a Y-shaped DNA structure on gold nanorods. Mikrochim Acta. 2020; 187(2):102. DOI: 10.1007/s00604-019-4089-y. View

12.

Altunbas O, Ozdas A, Yilmaz M . Luminescent detection of Ochratoxin A using terbium chelated mesoporous silica nanoparticles. J Hazard Mater. 2019; 382:121049. DOI: 10.1016/j.jhazmat.2019.121049. View

13.

van Egmond H, Schothorst R, Jonker M . Regulations relating to mycotoxins in food: perspectives in a global and European context. Anal Bioanal Chem. 2007; 389(1):147-57. DOI: 10.1007/s00216-007-1317-9. View

14.

Xu L, Zhang Z, Zhang Q, Li P . Mycotoxin Determination in Foods Using Advanced Sensors Based on Antibodies or Aptamers. Toxins (Basel). 2016; 8(8). PMC: 4999855. DOI: 10.3390/toxins8080239. View

15.

Lv X, Li Y, Yan T, Pang X, Cao W, Du B . Electrochemiluminescence modified electrodes based on RuSi@Ru(bpy)3(2+) loaded with gold functioned nanoporous CO/Co3O4 for detection of mycotoxin deoxynivalenol. Biosens Bioelectron. 2015; 70:28-33. DOI: 10.1016/j.bios.2015.03.020. View

16.

Jiang F, Li P, Zong C, Yang H . Surface-plasmon-coupled chemiluminescence amplification of silver nanoparticles modified immunosensor for high-throughput ultrasensitive detection of multiple mycotoxins. Anal Chim Acta. 2020; 1114:58-65. DOI: 10.1016/j.aca.2020.03.052. View

17.

Niazi S, Khan I, Yu Y, Pasha I, Shoaib M, Mohsin A . A "turnon" aptasensor for simultaneous and time-resolved fluorometric determination of zearalenone, trichothecenes A and aflatoxin B using WS as a quencher. Mikrochim Acta. 2019; 186(8):575. DOI: 10.1007/s00604-019-3570-y. View

18.

Sun C, Liao X, Jia B, Shi L, Zhang D, Wang R . Development of a ZnCdS@ZnS quantum dots-based label-free electrochemiluminescence immunosensor for sensitive determination of aflatoxin B in lotus seed. Mikrochim Acta. 2020; 187(4):236. DOI: 10.1007/s00604-020-4179-x. View

19.

Zhang W, Tang S, Jin Y, Yang C, He L, Wang J . Multiplex SERS-based lateral flow immunosensor for the detection of major mycotoxins in maize utilizing dual Raman labels and triple test lines. J Hazard Mater. 2020; 393:122348. DOI: 10.1016/j.jhazmat.2020.122348. View

20.

He D, Wu Z, Cui B, Jin Z, Xu E . A fluorometric method for aptamer-based simultaneous determination of two kinds of the fusarium mycotoxins zearalenone and fumonisin B making use of gold nanorods and upconversion nanoparticles. Mikrochim Acta. 2020; 187(4):254. DOI: 10.1007/s00604-020-04236-4. View