Associations Between Urinary Heavy Metal Concentrations and Blood Pressure in Residents of Asian Countries

Overview

Journal Environ Health Prev Med

Specialties Environmental Health
Public Health

Date 2021 Oct 9

PMID 34625018

Citations 6

Authors

Yuki Mizuno

Hana Shimizu-Furusawa

Shoko Konishi

Tsukasa Inaoka

Sk Akhtar Ahmad

Makiko Sekiyama

Oekan S Abdoellah

Budhi Gunawan

Rajendra Prasad Parajuli

Yukio Ikemoto

Tran Dinh Lam

Chiho Watanabe

Masahiro Umezaki

Affiliations

Soon will be listed here.

Abstract

Background: Previous studies have suggested that exposures to heavy metals (arsenic, cadmium, lead, and selenium) may be associated with differences in blood pressure. However, the findings of these studies have been inconsistent. This study was performed to examine the associations between urinary heavy metal concentrations and blood pressure among residents of four Asian countries (Bangladesh, Indonesia, Nepal, and Vietnam).

Methods: This cross-sectional study examined 1899 adults in four Asian countries. Urinary concentrations of heavy metals were measured by inductively coupled plasma mass spectrometry. A questionnaire survey was administered regarding individual characteristics. Anthropometric measurements (height and weight) were performed. Systolic and diastolic blood pressures were measured after a short rest. Multiple linear regression models were applied to investigate associations between urinary heavy metal concentrations and blood pressure after adjustments for age, sex, and body mass index.

Results: The geometric means of the urinary concentrations of arsenic, cadmium, lead, and selenium were 84.6, 0.885, 2.09, and 16.5 μg/g creatinine, respectively. The urinary arsenic concentrations were slightly higher than those typically reported in non-polluted populations, while urinary cadmium, lead, and selenium concentrations were equivalent or slightly lower. The urinary lead concentrations were positively associated with both systolic and diastolic blood pressure, but urinary selenium concentrations were negatively associated with them.

Conclusions: Variations in the urinary concentrations of lead and selenium were associated with blood pressure at low levels of exposure/intake.

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