Higher Urinary Heavy Metal, Phthalate, and Arsenic but Not Parabens Concentrations in People with High Blood Pressure, U.S. NHANES, 2011-2012

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2014 Jun 7

PMID 24905244

Citations 24

Authors

Ivy Shiue

Affiliations

Soon will be listed here.

Abstract

Link between environmental chemicals and human health has emerged but not been completely examined in risk factors. Therefore, it was aimed to study the relationships of different sets of urinary environmental chemical concentrations and risk of high blood pressure (BP) in a national, population-based study. Data were retrieved from United States National Health and Nutrition Examination Surveys, 2011-2012 including demographics, BP readings, and urinary environmental chemical concentrations. Analyses included chi-square test, t-test and survey-weighted logistic regression modeling. After full adjustment (adjusting for urinary creatinine, age, sex, ethnicity, and body mass index), urinary cesium (OR 1.56, 95%CI 1.11-2.20, P = 0.014), molybden (OR 1.46, 95%CI 1.06-2.01, P = 0.023), manganese (OR 1.42, 95%CI 1.09-1.86, P = 0.012), lead (OR 1.58, 95%CI 1.28-1.96, P < 0.001), tin (OR 1.44, 95%CI 1.25-1.66, P < 0.001), antimony (OR 1.39, 95%CI 1.10-1.77, P = 0.010), and tungsten (OR 1.49, 95%CI 1.25-1.77, P < 0.001) concentrations were observed to be associated with high BP. People with higher urinary mono-2-ethyl-5-carboxypentyl phthalate (OR 1.33, 95%CI 1.00-1.62, P = 0.006), mono-n-butyl phthalate (OR 1.35, 95%CI 1.13-1.62, P = 0.002), mono-2-ethyl-5-hydroxyhexyl (OR 1.25, 95%CI 1.05-1.49, P = 0.014), mono-n-methyl phthalate (OR 1.26, 95%CI 1.07-1.48, P = 0.007), mono-2-ethyl-5-oxohexyl (OR 1.25, 95%CI 1.07-1.48, P = 0.009), and monobenzyl phthalate (OR 1.40, 95%CI 1.15-1.69, P = 0.002) tended to have high BP as well. However, there are no clear associations between environmental parabens and high BP, nor between pesticides and high BP. In addition, trimethylarsine oxide (OR 2.47, 95%CI 1.27-4.81, P = 0.011) and dimethylarsonic acid concentrations (OR 1.42, 95%CI 1.12-1.79, P = 0.006) were seen to be associated with high BP. In sum, urinary heavy metal, phthalate, and arsenic concentrations were associated with high BP, although the causal effect cannot be established from the current study design. Elimination of environmental chemicals in humans would still need to be continued.

Citing Articles

Phthalates cause a low-renin phenotype commonly found in premature infants with idiopathic neonatal hypertension.

Jenkins R Pediatr Nephrol. 2022; 38(6):1717-1724.

PMID: 36322257 DOI: 10.1007/s00467-022-05773-1.

Linking the Low-Density Lipoprotein-Cholesterol (LDL) Level to Arsenic Acid, Dimethylarsinic, and Monomethylarsonic: Results from a National Population-Based Study from the NHANES, 2003-2020.

Qu C, Huang R Nutrients. 2022; 14(19).

PMID: 36235646 PMC: 9573665. DOI: 10.3390/nu14193993.

Association of urine phthalate metabolites, bisphenol A levels and serum electrolytes with 24-h blood pressure profile in adolescents.

Yalcin S, Erdal I, Oguz B, Duzova A BMC Nephrol. 2022; 23(1):141.

PMID: 35410150 PMC: 9004182. DOI: 10.1186/s12882-022-02774-y.

Maternal Phthalates Exposure and Blood Pressure during and after Pregnancy in the PROGRESS Study.

Wu H, Kupsco A, Just A, Calafat A, Oken E, Braun J Environ Health Perspect. 2021; 129(12):127007.

PMID: 34935432 PMC: 8693773. DOI: 10.1289/EHP8562.

First- and Third-Trimester Urinary Phthalate Metabolites in the Development of Hypertensive Diseases of Pregnancy.

Bedell S, Lyden G, Sathyanarayana S, Barrett E, Ferguson K, Santilli A Int J Environ Res Public Health. 2021; 18(20).

PMID: 34682373 PMC: 8536149. DOI: 10.3390/ijerph182010627.

References

Halden R . Plastics and health risks. Annu Rev Public Health. 2010; 31:179-94. DOI: 10.1146/annurev.publhealth.012809.103714. View

Jones M, Tellez-Plaza M, Sharrett A, Guallar E, Navas-Acien A . Urine arsenic and hypertension in US adults: the 2003-2008 National Health and Nutrition Examination Survey. Epidemiology. 2011; 22(2):153-61. PMC: 3388808. DOI: 10.1097/EDE.0b013e318207fdf2. View

Kumagai Y, Pi J . Molecular basis for arsenic-induced alteration in nitric oxide production and oxidative stress: implication of endothelial dysfunction. Toxicol Appl Pharmacol. 2004; 198(3):450-7. DOI: 10.1016/j.taap.2003.10.031. View

Schnorr T, Steenland K, Thun M, Rinsky R . Mortality in a cohort of antimony smelter workers. Am J Ind Med. 1995; 27(5):759-70. DOI: 10.1002/ajim.4700270510. View

Rogers J, Ellis-Hutchings R, Grey B, Zucker R, Norwood Jr J, Grace C . Elevated blood pressure in offspring of rats exposed to diverse chemicals during pregnancy. Toxicol Sci. 2013; 137(2):436-46. DOI: 10.1093/toxsci/kft248. View

Ye X, Kuklenyik Z, Bishop A, Needham L, Calafat A . Quantification of the urinary concentrations of parabens in humans by on-line solid phase extraction-high performance liquid chromatography-isotope dilution tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2006; 844(1):53-9. DOI: 10.1016/j.jchromb.2006.06.037. View

Patterson E, Szabo B, Scherlag B, LAZZARA R . Early and delayed afterdepolarizations associated with cesium chloride-induced arrhythmias in the dog. J Cardiovasc Pharmacol. 1990; 15(2):323-31. DOI: 10.1097/00005344-199002000-00021. View

Newbold R, Padilla-Banks E, Snyder R, Jefferson W . Developmental exposure to estrogenic compounds and obesity. Birth Defects Res A Clin Mol Teratol. 2005; 73(7):478-80. DOI: 10.1002/bdra.20147. View

Peuster M, Fink C, von Schnakenburg C, Hausdorf G . Dissolution of tungsten coils does not produce systemic toxicity, but leads to elevated levels of tungsten in the serum and recanalization of the previously occluded vessel. Cardiol Young. 2002; 12(3):229-35. DOI: 10.1017/s1047951102000513. View

10.

COTTON M, Logan M . Effects of antimony on the cardiovascular system and intestinal smooth muscle. J Pharmacol Exp Ther. 1966; 151(1):7-22. View

11.

Schafer S, Femfert U . Tin--a toxic heavy metal? A review of the literature. Regul Toxicol Pharmacol. 1984; 4(1):57-69. DOI: 10.1016/0273-2300(84)90006-0. View

12.

Norman R, Carpenter D, Scott J, Brune M, Sly P . Environmental exposures: an underrecognized contribution to noncommunicable diseases. Rev Environ Health. 2013; 28(1):59-65. DOI: 10.1515/reveh-2012-0033. View

13.

Revis N, Zinsmeister A, Bull R . Atherosclerosis and hypertension induction by lead and cadmium ions: an effect prevented by calcium ion. Proc Natl Acad Sci U S A. 1981; 78(10):6494-8. PMC: 349066. DOI: 10.1073/pnas.78.10.6494. View

14.

Cwikel J, Abdelgani A, Goldsmith J, Quastel M, Yevelson I . Two-year follow up study of stress-related disorders among immigrants to Israel from the Chernobyl area. Environ Health Perspect. 1998; 105 Suppl 6:1545-50. PMC: 1469946. DOI: 10.1289/ehp.97105s61545. View

15.

Vaziri N, Ding Y, Ni Z . Compensatory up-regulation of nitric-oxide synthase isoforms in lead-induced hypertension; reversal by a superoxide dismutase-mimetic drug. J Pharmacol Exp Ther. 2001; 298(2):679-85. View

16.

Zipf G, Chiappa M, Porter K, Ostchega Y, Lewis B, Dostal J . National health and nutrition examination survey: plan and operations, 1999-2010. Vital Health Stat 1. 2014; (56):1-37. View

17.

Fish F, Prakash C, Roden D . Suppression of repolarization-related arrhythmias in vitro and in vivo by low-dose potassium channel activators. Circulation. 1990; 82(4):1362-9. DOI: 10.1161/01.cir.82.4.1362. View

18.

Heudorf U, Mersch-Sundermann V, Angerer J . Phthalates: toxicology and exposure. Int J Hyg Environ Health. 2007; 210(5):623-34. DOI: 10.1016/j.ijheh.2007.07.011. View

19.

DAlonzo A, Hess T, Darbenzio R, Sewter J . Effects of intracoronary cromakalim, pinacidil, or diltiazem on cesium chloride-induced arrhythmias in anesthetized dogs under conditions of controlled coronary blood flow. J Cardiovasc Pharmacol. 1993; 21(4):677-83. DOI: 10.1097/00005344-199304000-00024. View

20.

Bisset K, Dhopeshwarkar A, Liao C, Nicholson R . The G protein-coupled cannabinoid-1 (CB1) receptor of mammalian brain: inhibition by phthalate esters in vitro. Neurochem Int. 2011; 59(5):706-13. DOI: 10.1016/j.neuint.2011.06.019. View