The Roles of Quercetin in Diabetes Mellitus and Related Metabolic Disorders; Special Focus on the Modulation of Gut Microbiota: A Comprehensive Review

Quercetin is a dietary flavonoid that can affect the balance between anti-oxidant defense system and oxidative stress. A number of studies showed the positive effects of quercetin on diabetes mellitus and related metabolic disorders Therefore, the aims of were investigate the effect of quercetin on diabetes mellitus and related metabolic disorders by focusing on its effects on the modulation of gut microbiota. For this purpose, findings of , and review studies were summarized. They were identified quercetin can be an effective component for improving glycemic status and other metabolic disorders related to diabetes mellitus based on and animal studies. However, environmental factors, food processing and using nanoformulations can affect its efficacy in human studies. Several potential mechanisms, including the modulation of gut flora are proposed for its actions. , more high-quality clinical trials are needed to make a decision on the efficacy of supplementation with quercetin as a complementary therapy for the management of diabetes mellitus, metabolic disorders, and modulating gut flora.