Advances in Chromodomain Helicase DNA-Binding (CHD) Proteins Regulating Stem Cell Differentiation and Human Diseases

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2021 Oct 7

PMID 34616726

Citations 6

Authors

Caojie Liu

Ning Kang

Yuchen Guo

Ping Gong

Affiliations

Soon will be listed here.

Abstract

Regulation of gene expression is critical for stem cell differentiation, tissue development, and human health maintenance. Recently, epigenetic modifications of histone and chromatin remodeling have been verified as key controllers of gene expression and human diseases. In this study, we review the role of chromodomain helicase DNA-binding (CHD) proteins in stem cell differentiation, cell fate decision, and several known human developmental disorders and cancers. CHD proteins play a crucial role in stem cell differentiation and human diseases.

Citing Articles

Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study.

Wu Y, Lin Z, Li C, Lin X, Shan S, Guo B Signal Transduct Target Ther. 2023; 8(1):98.

PMID: 36864020 PMC: 9981733. DOI: 10.1038/s41392-023-01333-7.

CHD1, a multifaceted epigenetic remodeler in prostate cancer.

Li H, Gigi L, Zhao D Front Oncol. 2023; 13:1123362.

PMID: 36776288 PMC: 9909554. DOI: 10.3389/fonc.2023.1123362.

Discovery of Novel Variants on the Gene: A Case Series of CHARGE Syndrome.

Wu X, Chen L, Lu W, He S, Li X, Sun L Front Genet. 2022; 13:852429.

PMID: 35938004 PMC: 9355507. DOI: 10.3389/fgene.2022.852429.

CHD Chromatin Remodeling Protein Diversification Yields Novel Clades and Domains Absent in Classic Model Organisms.

Trujillo J, Long J, Aboelnour E, Ogas J, Wisecaver J Genome Biol Evol. 2022; 14(5).

PMID: 35524943 PMC: 9113485. DOI: 10.1093/gbe/evac066.

CHD7 regulates bone-fat balance by suppressing PPAR-γ signaling.

Liu C, Xiong Q, Li Q, Lin W, Jiang S, Zhang D Nat Commun. 2022; 13(1):1989.

PMID: 35418650 PMC: 9007978. DOI: 10.1038/s41467-022-29633-6.

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