Polymorphisms and Their Association with Prostate Cancer Risk in Japanese Men

Overview

Journal J Prev Med Hyg

Specialty Public Health

Date 2021 Oct 4

PMID 34604590

Citations 1

Authors

Takuji Hinoura

Shoichiro Mukai

Toshiyuki Kamoto

Yoshiki Kuroda

Affiliations

Soon will be listed here.

Abstract

Introduction: Prostate cancer (PCa) is one of the most common cancers affecting men globally. Although PER3 has been suggested as a risk factor for cancer development, there are few reports elucidating the relationship between PER3 and PCa. We investigated the association between PER3 polymorphisms (rs2640908 and VNTR) and susceptibility to PCa in the Japanese population.

Methods: Eighty three patients with PCa and 122 controls participated in this study. We analyzed rs2640908 and VNTR polymorphisms by using PCR-Restriction Fragment Length Polymorphism (PCR-RFLP).

Results: Compared to the C/C genotype with the rs2640908 polymorphism, the T/T (OR: 0.35, 95% CI: 0.15-0.81, P = 0.02) and C/T + T/T (OR: 0.46, 95% CI: 0.24-0.88, P = 0.02) genotypes had a significantly lower risk of PCa. TT (OR: 0.29, 95% CI: 0.10-0.77, P = 0.02) and CT + TT (OR: 0.47, 95% CI: 0.23-0.97, P = 0.04) also had significant protection against PCa in the smoker group. Significantly, we observed an association between smoking and rs2640908 polymorphism in this study. However, no association between the VNTR polymorphisms and PCa was detected.

Conclusions: Our results suggest that PER3 rs2640908 polymorphisms influence an individual's susceptibility to PCa.

Citing Articles

Biological clock regulation by the gene family: a new perspective on tumor development.

Chen K, Wang Y, Li D, Wu R, Wang J, Wei W Front Cell Dev Biol. 2024; 12:1332506.

PMID: 38813085 PMC: 11133573. DOI: 10.3389/fcell.2024.1332506.

References

DeBruyne J, Weaver D, Reppert S . CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock. Nat Neurosci. 2007; 10(5):543-5. PMC: 2782643. DOI: 10.1038/nn1884. View

Zhu Y, Brown H, Zhang Y, Stevens R, Zheng T . Period3 structural variation: a circadian biomarker associated with breast cancer in young women. Cancer Epidemiol Biomarkers Prev. 2005; 14(1):268-70. View

Reszka E, Wieczorek E, Przybek M, Jablonska E, Kaluzny P, Bukowska-Damska A . Circadian gene methylation in rotating-shift nurses: a cross-sectional study. Chronobiol Int. 2017; 35(1):111-121. DOI: 10.1080/07420528.2017.1388252. View

Yu C, Chen L, Chiou C, Chang Y, Lin V, Huang C . Genetic variants in the circadian rhythm pathway as indicators of prostate cancer progression. Cancer Cell Int. 2019; 19:87. PMC: 6451277. DOI: 10.1186/s12935-019-0811-4. View

Archer S, Robilliard D, Skene D, Smits M, Williams A, Arendt J . A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference. Sleep. 2003; 26(4):413-5. DOI: 10.1093/sleep/26.4.413. View

Climent J, Perez-Losada J, Quigley D, Kim I, Delrosario R, Jen K . Deletion of the PER3 gene on chromosome 1p36 in recurrent ER-positive breast cancer. J Clin Oncol. 2010; 28(23):3770-8. PMC: 2917310. DOI: 10.1200/JCO.2009.27.0215. View

Yamauchi T, Takeuchi S, Maehara N, Kuroda Y . The genotype of the transporter associated with antigen processing gene affects susceptibility to colorectal cancer in Japanese. Environ Health Prev Med. 2014; 19(4):265-70. PMC: 4085250. DOI: 10.1007/s12199-014-0388-4. View

Alexander M, Burch J, Steck S, Chen C, Hurley T, Cavicchia P . Case-control study of the PERIOD3 clock gene length polymorphism and colorectal adenoma formation. Oncol Rep. 2014; 33(2):935-41. PMC: 4306271. DOI: 10.3892/or.2014.3667. View

Guess J, Burch J, Ogoussan K, Armstead C, Zhang H, Wagner S . Circadian disruption, Per3, and human cytokine secretion. Integr Cancer Ther. 2009; 8(4):329-36. PMC: 2959170. DOI: 10.1177/1534735409352029. View

10.

Yang M, Chang J, Lin P, Tang K, Chen Y, Lin H . Downregulation of circadian clock genes in chronic myeloid leukemia: alternative methylation pattern of hPER3. Cancer Sci. 2006; 97(12):1298-307. PMC: 11160076. DOI: 10.1111/j.1349-7006.2006.00331.x. View

11.

Asher G, Schibler U . A CLOCK-less clock. Trends Cell Biol. 2006; 16(11):547-9. DOI: 10.1016/j.tcb.2006.09.005. View

12.

Huang X, Fu C, Bu R . Role of circadian clocks in the development and therapeutics of cancer. J Int Med Res. 2012; 39(6):2061-6. DOI: 10.1177/147323001103900601. View

13.

Chu L, Zhu Y, Yu K, Zheng T, Yu H, Zhang Y . Variants in circadian genes and prostate cancer risk: a population-based study in China. Prostate Cancer Prostatic Dis. 2007; 11(4):342-8. DOI: 10.1038/sj.pcan.4501024. View

14.

Zhao B, Lu J, Yin J, Liu H, Guo X, Yang Y . A functional polymorphism in PER3 gene is associated with prognosis in hepatocellular carcinoma. Liver Int. 2012; 32(9):1451-9. DOI: 10.1111/j.1478-3231.2012.02849.x. View

15.

Oshima T, Takenoshita S, Akaike M, Kunisaki C, Fujii S, Nozaki A . Expression of circadian genes correlates with liver metastasis and outcomes in colorectal cancer. Oncol Rep. 2011; 25(5):1439-46. DOI: 10.3892/or.2011.1207. View

16.

Markt S, Valdimarsdottir U, Shui I, Sigurdardottir L, Rider J, Tamimi R . Circadian clock genes and risk of fatal prostate cancer. Cancer Causes Control. 2014; 26(1):25-33. PMC: 4282953. DOI: 10.1007/s10552-014-0478-z. View

17.

Zienolddiny S, Haugen A, Sigstad Lie J, Kjuus H, Anmarkrud K, Kjaerheim K . Analysis of polymorphisms in the circadian-related genes and breast cancer risk in Norwegian nurses working night shifts. Breast Cancer Res. 2013; 15(4):R53. PMC: 3978690. DOI: 10.1186/bcr3445. View

18.

Wendeu-Foyet M, Menegaux F . Circadian Disruption and Prostate Cancer Risk: An Updated Review of Epidemiological Evidences. Cancer Epidemiol Biomarkers Prev. 2017; 26(7):985-991. DOI: 10.1158/1055-9965.EPI-16-1030. View

19.

Rutter J, Reick M, Wu L, McKnight S . Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors. Science. 2001; 293(5529):510-4. DOI: 10.1126/science.1060698. View

20.

Kume K, Zylka M, Sriram S, Shearman L, Weaver D, Jin X . mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell. 1999; 98(2):193-205. DOI: 10.1016/s0092-8674(00)81014-4. View