Photoredox-Catalyzed C-H Functionalization Reactions

Overview

Journal Chem Rev

Publisher American Chemical Society

Specialty Chemistry

Date 2021 Sep 29

PMID 34585909

Citations 93

Authors

Natalie Holmberg-Douglas

David A Nicewicz

Affiliations

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Abstract

The fields of C-H functionalization and photoredox catalysis have garnered enormous interest and utility in the past several decades. Many different scientific disciplines have relied on C-H functionalization and photoredox strategies including natural product synthesis, drug discovery, radiolabeling, bioconjugation, materials, and fine chemical synthesis. In this Review, we highlight the use of photoredox catalysis in C-H functionalization reactions. We separate the review into inorganic/organometallic photoredox catalysts and organic-based photoredox catalytic systems. Further subdivision by reaction class─either sp or sp C-H functionalization─lends perspective and tactical strategies for use of these methods in synthetic applications.

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