ILC2s in Virus-induced Asthma Exacerbations: A Starring or Supportive Role?

Overview

Journal Am J Respir Crit Care Med

Specialty Critical Care

Date 2021 Sep 28

PMID 34582713

Authors

Marc B Hershenson

Affiliations

Soon will be listed here.

References

Huang Y, Guo L, Qiu J, Chen X, Hu-Li J, Siebenlist U . IL-25-responsive, lineage-negative KLRG1(hi) cells are multipotential 'inflammatory' type 2 innate lymphoid cells. Nat Immunol. 2014; 16(2):161-9. PMC: 4297567. DOI: 10.1038/ni.3078. View

Zhu Z, Hasegawa K, Ma B, Fujiogi M, Camargo Jr C, Liang L . Association of asthma and its genetic predisposition with the risk of severe COVID-19. J Allergy Clin Immunol. 2020; 146(2):327-329.e4. PMC: 7423602. DOI: 10.1016/j.jaci.2020.06.001. View

Demore J, Weisshaar E, Vrtis R, Swenson C, Evans M, Morin A . Similar colds in subjects with allergic asthma and nonatopic subjects after inoculation with rhinovirus-16. J Allergy Clin Immunol. 2009; 124(2):245-52, 252.e1-3. PMC: 2737589. DOI: 10.1016/j.jaci.2009.05.030. View

Ferreira A, Szeto A, Heycock M, Clark P, Walker J, Crisp A . RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus. Nat Immunol. 2021; 22(2):166-178. PMC: 7116838. DOI: 10.1038/s41590-020-00833-w. View

Han M, Ishikawa T, Stroupe C, Breckenridge H, Bentley J, Hershenson M . Deficient inflammasome activation permits an exaggerated asthma phenotype in rhinovirus C-infected immature mice. Mucosal Immunol. 2021; 14(6):1369-1380. PMC: 8542611. DOI: 10.1038/s41385-021-00436-0. View

Heymann P, Platts-Mills T, Woodfolk J, Borish L, Murphy D, Carper H . Understanding the asthmatic response to an experimental rhinovirus infection: Exploring the effects of blocking IgE. J Allergy Clin Immunol. 2020; 146(3):545-554. PMC: 7733370. DOI: 10.1016/j.jaci.2020.01.035. View

Price A, Liang H, Sullivan B, Reinhardt R, Eisley C, Erle D . Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc Natl Acad Sci U S A. 2010; 107(25):11489-94. PMC: 2895098. DOI: 10.1073/pnas.1003988107. View

Ohne Y, Silver J, Thompson-Snipes L, Collet M, Blanck J, Cantarel B . IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity. Nat Immunol. 2016; 17(6):646-55. DOI: 10.1038/ni.3447. View

Molofsky A, Van Gool F, Liang H, Van Dyken S, Nussbaum J, Lee J . Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation. Immunity. 2015; 43(1):161-74. PMC: 4512852. DOI: 10.1016/j.immuni.2015.05.019. View

10.

Neill D, Wong S, Bellosi A, Flynn R, Daly M, Langford T . Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature. 2010; 464(7293):1367-70. PMC: 2862165. DOI: 10.1038/nature08900. View

11.

Chairakaki A, Saridaki M, Pyrillou K, Mouratis M, Koltsida O, Walton R . Plasmacytoid dendritic cells drive acute asthma exacerbations. J Allergy Clin Immunol. 2017; 142(2):542-556.e12. DOI: 10.1016/j.jaci.2017.08.032. View

12.

Monticelli L, Sonnenberg G, Abt M, Alenghat T, Ziegler C, Doering T . Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat Immunol. 2011; 12(11):1045-54. PMC: 3320042. DOI: 10.1031/ni.2131. View

13.

Dhariwal J, Cameron A, Wong E, Paulsen M, Trujillo-Torralbo M, Del Rosario A . Pulmonary Innate Lymphoid Cell Responses during Rhinovirus-induced Asthma Exacerbations : A Clinical Trial. Am J Respir Crit Care Med. 2021; 204(11):1259-1273. PMC: 8786078. DOI: 10.1164/rccm.202010-3754OC. View

14.

Bentley J, Sajjan U, Dzaman M, Jarjour N, Lee W, Gern J . Rhinovirus colocalizes with CD68- and CD11b-positive macrophages following experimental infection in humans. J Allergy Clin Immunol. 2013; 132(3):758-761.e3. PMC: 3759653. DOI: 10.1016/j.jaci.2013.04.020. View

15.

Jazaeri S, Goldsmith A, Jarman C, Lee J, Hershenson M, Lewis T . Nasal interferon responses to community rhinovirus infections are similar in controls and children with asthma. Ann Allergy Asthma Immunol. 2021; 126(6):690-695.e1. PMC: 8164986. DOI: 10.1016/j.anai.2021.01.023. View

16.

Han M, Ishikawa T, Bermick J, Rajput C, Lei J, Goldsmith A . IL-1β prevents ILC2 expansion, type 2 cytokine secretion, and mucus metaplasia in response to early-life rhinovirus infection in mice. Allergy. 2020; 75(8):2005-2019. PMC: 8066359. DOI: 10.1111/all.14241. View

17.

Halim T, Steer C, Matha L, Gold M, Martinez-Gonzalez I, McNagny K . Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation. Immunity. 2014; 40(3):425-35. PMC: 4210641. DOI: 10.1016/j.immuni.2014.01.011. View

18.

Bal S, Bernink J, Nagasawa M, Groot J, Shikhagaie M, Golebski K . IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs. Nat Immunol. 2016; 17(6):636-45. DOI: 10.1038/ni.3444. View