Localization of the Human Pim Oncogene (PIM) to a Region of Chromosome 6 Involved in Translocations in Acute Leukemias

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1986 Apr 1

PMID 3458216

Citations 31

Authors

L Nagarajan

E Louie

Y Tsujimoto

K Huebner

C M Croce

Affiliations

Soon will be listed here.

Abstract

The human homolog, hpim, of the murine pim-1 gene, which is activated in murine T-cell lymphomas by insertion of retrovirus proviral genomes in the pim-1 region, has been molecularly cloned; the cloned probe has been used to map the hpim locus to human chromosome region 6p21 by somatic cell hybrid analysis and chromosomal in situ hybridization. The hpim gene is expressed as a 3.2-kilobase mRNA in various human cell lines of hematopoietic lineage, most dramatically in the K562 erythroleukemia cell line, which contains a cytogenetically demonstrable rearrangement in the 6p21 region. A characteristic chromosome anomaly, a reciprocal translocation t(6;9)(p21;q33), has been described in myeloid leukemias and could involve the hpim gene.

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