Integration of in Vitro Allergy Test Results and Ratio Analysis for the Diagnosis and Treatment of Allergic Patients (INTEGRA)

Overview

Journal Clin Transl Allergy

Publisher Wiley

Specialty Allergy & Immunology

Date 2021 Sep 28

PMID 34582103

Citations 5

Authors

Mariona Pascal

Carmen Moreno

Ignacio Davila

Ana I Tabar

Joan Bartra

Moises Labrador

Olga Luengo

Affiliations

Soon will be listed here.

Abstract

The introduction of molecular diagnosis into routine clinical practice has substantially improved the diagnosis and management of allergic patients by allowing clinicians to precisely identify the allergenic molecule responsible for immunoglobulin E (IgE)-mediated allergies. However, it can be challenging to accurately interpret the results of molecular assays, partly due to the limited evidence base. In this context, a panel of experts with extensive experience in interpreting in vitro measures of total and serum specific IgE reviewed the available scientific evidence. After this review, the panel selected a series of representative case studies to demonstrate how determination of specific and total IgE values and the relationship between them (ratio analysis) can add value to the diagnostic process by more precisely defining the patient's sensitization profile. Finally, the experts developed a series of recommendations on the clinical application of ratio analysis to optimize and complement the classical approach to allergy diagnosis.

Citing Articles

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Low Levels Matter: Clinical Relevance of Low Pru p 3 sIgE in Patients With Peach Allergy.

Balsells-Vives S, San Bartolome C, Casas-Saucedo R, Ruano-Zaragoza M, Rius J, Torradeflot M Front Allergy. 2022; 3:868267.

PMID: 35769570 PMC: 9234939. DOI: 10.3389/falgy.2022.868267.

Integration of in vitro allergy test results and ratio analysis for the diagnosis and treatment of allergic patients (INTEGRA).

Pascal M, Moreno C, Davila I, Tabar A, Bartra J, Labrador M Clin Transl Allergy. 2021; 11(7):e12052.

PMID: 34582103 PMC: 9082998. DOI: 10.1002/clt2.12052.

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