Effects of a Postbiotic and Prebiotic Mixture on Suckling Rats' Microbiota and Immunity

Overview

Journal Nutrients

Date 2021 Sep 28

PMID 34578853

Citations 10

Authors

Carla Morales-Ferre

Ignasi Azagra-Boronat

Malen Massot-Cladera

Sebastian Tims

Karen Knipping

Johan Garssen

Jan Knol

Angels Franch

Margarida Castell

Maria J Rodriguez-Lagunas

Francisco J Perez-Cano

Affiliations

Soon will be listed here.

Abstract

Human milk serves as a model for infant formula providing nutritional solutions for infants not able to receive enough mother's milk. Infant formulas aim to mimic the composition and functionality of human milk by providing ingredients reflecting those of the latest human milk insights, such as prebiotics, probiotics and postbiotics. The aim of this study was to examine the effects of the supplementation with a postbiotic (Lactofidus) and its combination with the prebiotics short-chain galactooligosaccharides (scGOS) and long-chain fructooligosaccharides (lcFOS) in a preclinical model of healthy suckling rats. Pups were supplemented daily with Lactofidus (POST group) and/or scGOS/lcFOS (P+P and PRE groups, respectively). Body weight and fecal consistency were analyzed. At the end of the study, immunoglobulin (Ig) profile, intestinal gene expression, microbiota composition and short chain fatty acid (SCFA) proportion were quantified. The supplementation with all nutritional interventions modulated the Ig profile, but the prebiotic mixture and the postbiotic induced differential effects: whereas scGOS/lcFOS induced softer feces and modulated microbiota composition and SCFA profile, Lactofidus™ upregulated Toll-like receptors gene expression. The use of the combination of scGOS/lcFOS and Lactofidus™ showed the effects observed for the oligosaccharides separately, as well as showing a synergistic impact on animal growth. Thus, the combined use of both products seems to be a good strategy to modulate immune and microbial features in early life.

Citing Articles

Impact of maternal ve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk composition.

Saez-Fuertes L, Kapravelou G, Grases-Pinto B, Massot-Cladera M, Bernabeu M, Knipping K Front Immunol. 2024; 15:1418594.

PMID: 38975337 PMC: 11224147. DOI: 10.3389/fimmu.2024.1418594.

Maternal Synbiotic Supplementation with M-16V and scGOS/lcFOS Shape Offspring Immune Development and Gut Microbiota at the End of Suckling.

Saez-Fuertes L, Kapravelou G, Grases-Pinto B, Bernabeu M, Knipping K, Garssen J Nutrients. 2024; 16(12).

PMID: 38931246 PMC: 11206815. DOI: 10.3390/nu16121890.

JS-3 Isolated from "Jiangshui" Ameliorates Hyperuricemia by Regulating Gut Microbiota and iTS Metabolism.

Wu J, Aga L, Tang L, Li H, Wang N, Yang L Foods. 2024; 13(9).

PMID: 38731742 PMC: 11083236. DOI: 10.3390/foods13091371.

Bioactives and their roles in bone metabolism of osteoarthritis: evidence and mechanisms on gut-bone axis.

Basak S, Hridayanka K, Duttaroy A Front Immunol. 2024; 14:1323233.

PMID: 38235147 PMC: 10792057. DOI: 10.3389/fimmu.2023.1323233.

Agaricus subrufescens fermented rye affects the development of intestinal microbiota, local intestinal and innate immunity in suckling-to-nursery pigs.

Wen C, Geervliet M, de Vries H, Faba L, den Hil P, Skovgaard K Anim Microbiome. 2023; 5(1):24.

PMID: 37041617 PMC: 10088699. DOI: 10.1186/s42523-023-00244-w.

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