Progress of 3D Bioprinting in Organ Manufacturing

Overview

Journal Polymers (Basel)

Publisher MDPI

Date 2021 Sep 28

PMID 34578079

Citations 15

Authors

Dabin Song

Yukun Xu

Siyu Liu

Liang Wen

Xiaohong Wang

Affiliations

Soon will be listed here.

Abstract

Three-dimensional (3D) bioprinting is a family of rapid prototyping technologies, which assemble biomaterials, including cells and bioactive agents, under the control of a computer-aided design model in a layer-by-layer fashion. It has great potential in organ manufacturing areas with the combination of biology, polymers, chemistry, engineering, medicine, and mechanics. At present, 3D bioprinting technologies can be used to successfully print living tissues and organs, including blood vessels, skin, bones, cartilage, kidney, heart, and liver. The unique advantages of 3D bioprinting technologies for organ manufacturing have improved the traditional medical level significantly. In this article, we summarize the latest research progress of polymers in bioartificial organ 3D printing areas. The important characteristics of the printable polymers and the typical 3D bioprinting technologies for several complex bioartificial organs, such as the heart, liver, nerve, and skin, are introduced.

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References

Feng Z, Wang D, Zheng Y, Zhao L, Xu T, Guo Z . A novel waterborne polyurethane with biodegradability and high flexibility for 3D printing. Biofabrication. 2020; 12(3):035015. DOI: 10.1088/1758-5090/ab7de0. View

Gao G, Hubbell K, Schilling A, Dai G, Cui X . Bioprinting Cartilage Tissue from Mesenchymal Stem Cells and PEG Hydrogel. Methods Mol Biol. 2017; 1612:391-398. DOI: 10.1007/978-1-4939-7021-6_28. View

Liu W, Zhang Y, Heinrich M, De Ferrari F, Lin Jang H, Bakht S . Rapid Continuous Multimaterial Extrusion Bioprinting. Adv Mater. 2016; 29(3). PMC: 5235978. DOI: 10.1002/adma.201604630. View

Elomaa L, Keshi E, Sauer I, Weinhart M . Development of GelMA/PCL and dECM/PCL resins for 3D printing of acellular in vitro tissue scaffolds by stereolithography. Mater Sci Eng C Mater Biol Appl. 2020; 112:110958. DOI: 10.1016/j.msec.2020.110958. View

Ricci J, Clark E, Murriky A, Smay J . Three-dimensional printing of bone repair and replacement materials: impact on craniofacial surgery. J Craniofac Surg. 2012; 23(1):304-8. DOI: 10.1097/SCS.0b013e318241dc6e. View

Duan P, Pan Z, Cao L, Gao J, Yao H, Liu X . Restoration of osteochondral defects by implanting bilayered poly(lactide--glycolide) porous scaffolds in rabbit joints for 12 and 24 weeks. J Orthop Translat. 2019; 19:68-80. PMC: 6896725. DOI: 10.1016/j.jot.2019.04.006. View

Wang X . Bioartificial Organ Manufacturing Technologies. Cell Transplant. 2018; 28(1):5-17. PMC: 6322143. DOI: 10.1177/0963689718809918. View

Yan Y, Wang X, Pan Y, Liu H, Cheng J, Xiong Z . Fabrication of viable tissue-engineered constructs with 3D cell-assembly technique. Biomaterials. 2005; 26(29):5864-71. DOI: 10.1016/j.biomaterials.2005.02.027. View

Ianchis R, Ninciuleanu C, Gifu I, Alexandrescu E, Nistor C, Nitu S . Hydrogel-clay Nanocomposites as Carriers for Controlled Release. Curr Med Chem. 2018; 27(6):919-954. DOI: 10.2174/0929867325666180831151055. View

10.

Murariu M, Dubois P . PLA composites: From production to properties. Adv Drug Deliv Rev. 2016; 107:17-46. DOI: 10.1016/j.addr.2016.04.003. View

11.

Kundu J, Shim J, Jang J, Kim S, Cho D . An additive manufacturing-based PCL-alginate-chondrocyte bioprinted scaffold for cartilage tissue engineering. J Tissue Eng Regen Med. 2013; 9(11):1286-97. DOI: 10.1002/term.1682. View

12.

Mallis P, Oikonomidis C, Dimou Z, Stavropoulos-Giokas C, Michalopoulos E, Katsimpoulas M . Optimizing Decellularization Strategies for the Efficient Production of Whole Rat Kidney Scaffolds. Tissue Eng Regen Med. 2021; 18(4):623-640. PMC: 8325734. DOI: 10.1007/s13770-021-00339-y. View

13.

Kumar H, Kim K . Stereolithography 3D Bioprinting. Methods Mol Biol. 2020; 2140:93-108. DOI: 10.1007/978-1-0716-0520-2_6. View

14.

Chinzei R, Tanaka Y, Shimizu-Saito K, Hara Y, Kakinuma S, Watanabe M . Embryoid-body cells derived from a mouse embryonic stem cell line show differentiation into functional hepatocytes. Hepatology. 2002; 36(1):22-9. DOI: 10.1053/jhep.2002.34136. View

15.

Serpelloni M, Cantu E, Borghetti M, Sardini E . Printed Smart Devices on Cellulose-Based Materials by means of Aerosol-Jet Printing and Photonic Curing. Sensors (Basel). 2020; 20(3). PMC: 7038689. DOI: 10.3390/s20030841. View

16.

Xu Y, Wang X . Fluid and cell behaviors along a 3D printed alginate/gelatin/fibrin channel. Biotechnol Bioeng. 2015; 112(8):1683-95. DOI: 10.1002/bit.25579. View

17.

Li S, Tian X, Fan J, Tong H, Ao Q, Wang X . Chitosans for Tissue Repair and Organ Three-Dimensional (3D) Bioprinting. Micromachines (Basel). 2019; 10(11). PMC: 6915415. DOI: 10.3390/mi10110765. View

18.

Zhu W, Qu X, Zhu J, Ma X, Patel S, Liu J . Direct 3D bioprinting of prevascularized tissue constructs with complex microarchitecture. Biomaterials. 2017; 124:106-115. PMC: 5330288. DOI: 10.1016/j.biomaterials.2017.01.042. View

19.

Cortes H, Caballero-Floran I, Mendoza-Munoz N, Cordova-Villanueva E, Escutia-Guadarrama L, Figueroa-Gonzalez G . Hyaluronic acid in wound dressings. Cell Mol Biol (Noisy-le-grand). 2020; 66(4):191-198. View

20.

Baltazar T, Merola J, Catarino C, Xie C, Kirkiles-Smith N, Lee V . Three Dimensional Bioprinting of a Vascularized and Perfusable Skin Graft Using Human Keratinocytes, Fibroblasts, Pericytes, and Endothelial Cells. Tissue Eng Part A. 2019; 26(5-6):227-238. PMC: 7476394. DOI: 10.1089/ten.TEA.2019.0201. View